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dc.contributor.authorS. McCarthy, Jamesen_US
dc.contributor.authorF. Good, Michaelen_US
dc.date.accessioned2017-04-24T12:31:11Z
dc.date.available2017-04-24T12:31:11Z
dc.date.issued2010en_US
dc.date.modified2011-04-07T05:31:38Z
dc.identifier.issn15548600en_US
dc.identifier.doi10.4161/hv.6.1.10394en_AU
dc.identifier.urihttp://hdl.handle.net/10072/37995
dc.description.abstractThere is a growing realization of the limitations of recombinant protein-based malaria vaccines. This, coupled with a better understanding of the protective immunity to malaria, both in animal models and in naturally exposed human populations and experimentally infected volunteers, as well as the increased capacity to manipulate parasites provides new impetus to evaluate whole blood stage parasite approaches to malaria vaccine development. In this review previous studies in rodents and primates of whole killed and attenuated blood stage vaccines, and recent work on the effect of genetically attenuated parasites on immunity in rodent models of blood stage immunity are discussed. The relationship between these findings and what is now known about protective immunity in human populations, specifically against the blood stages of the parasite lifecycle is discussed and recent findings from human experimental infection are be reviewed. Finally, the prospect for and impediments to the development whole blood stage parasites are revieweden_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherLandes Bioscienceen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom114en_US
dc.relation.ispartofpageto123en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalHuman Vaccinesen_US
dc.relation.ispartofvolume6en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchInfectious Diseasesen_US
dc.subject.fieldofresearchcode110309en_US
dc.titleWhole parasite blood stage malaria vaccines A convergence of evidenceen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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