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  • Correlation between bioluminescence and bacterial burden in passively protected mice challenged with a recombinant bioluminescent M49 group A streptococcus Strain

    Author(s)
    Sheel, Meru
    Pandey, Manisha
    Good, Michael Francis
    Batzloff, Michael R
    Griffith University Author(s)
    Good, Michael F.
    Pandey, Manisha
    Year published
    2010
    Metadata
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    Abstract
    Streptococcus pyogenes, also known as group A streptococcus (GAS), is a human pathogen which infects people of all age groups. Previous work has reported that conformationally constrained chimeric peptide J8 protects against GAS challenge. In the current study, we demonstrate the utility of bioluminescent imaging as a rapid technique for monitoring bacterial dissemination following the passive transfer of rabbit anti-J8 antibodies to naïve mice and subsequent challenge with recombinant GAS strain M49, an emm type shown to be associated with poststreptococcal glomerular nephritisStreptococcus pyogenes, also known as group A streptococcus (GAS), is a human pathogen which infects people of all age groups. Previous work has reported that conformationally constrained chimeric peptide J8 protects against GAS challenge. In the current study, we demonstrate the utility of bioluminescent imaging as a rapid technique for monitoring bacterial dissemination following the passive transfer of rabbit anti-J8 antibodies to naïve mice and subsequent challenge with recombinant GAS strain M49, an emm type shown to be associated with poststreptococcal glomerular nephritis
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    Journal Title
    Clinical and Vaccine Immunology
    Volume
    17
    Issue
    1
    DOI
    https://doi.org/10.1128/CVI.00256-09
    Subject
    Infectious diseases
    Immunology
    Publication URI
    http://hdl.handle.net/10072/37996.1
    Collection
    • Journal articles

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