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dc.contributor.authorGeorge, Joanne M
dc.contributor.authorFiori, Simona
dc.contributor.authorFripp, Jurgen
dc.contributor.authorPannek, Kerstin
dc.contributor.authorGuzzetta, Andrea
dc.contributor.authorDavid, Michael
dc.contributor.authorWare, Robert S
dc.contributor.authorRose, Stephen E
dc.contributor.authorColditz, Paul B
dc.contributor.authorBoyd, Roslyn N
dc.date.accessioned2019-05-29T13:05:08Z
dc.date.available2019-05-29T13:05:08Z
dc.date.issued2018
dc.identifier.issn0378-3782
dc.identifier.doi10.1016/j.earlhumdev.2017.12.014
dc.identifier.urihttp://hdl.handle.net/10072/379972
dc.description.abstractAim: This study aimed to examine associations between structural MRI and concurrent motor, neurological andneurobehavioral measures at 30–32 weeks postmenstrual age (PMA; ‘Early’), and at term equivalent age(‘Term’).Method: In this prospective cohort study, infants underwent Early MRI (n = 119; 73 male; median 32 weeks1 day PMA) and Term MRI (n = 102; 61 male; median 40 weeks 4 days PMA) at 3 T. Structural images werescored generating white matter (WM), cortical gray matter, deep gray matter, cerebellar and global brain ab-normality scores. Clinical measures were General Movements Assessment (GMs), Hammersmith NeonatalNeurological Examination (HNNE) and NICU Neonatal Neurobehavioral Scale (NNNS). The Premie-Neuro wasadministered Early and the Test of Infant Motor Performance (TIMP) and a visual assessment at Term.Results: Early MRI cerebellar scores were strongly associated with neurological components of HNNE (reflexes),NNNS (Hypertonicity), the Premie-Neuro neurological subscale (regression coefficient β = −0.06; 95% con-fidence interval CI = −0.09, −0.04; p < .001) and cramped-synchronized GMs (β = 1.10; 95%CI = 0.57,1.63; p < .001). Term MRI WM and global scores were strongly associated with the TIMP (WM β = −1.02;95%CI = −1.67, −0.36; p = .002; global β = −1.59; 95%CI = −2.62, −0.56; p = .001).Interpretation: Brain structure on Early and Term MRI was associated with concurrent motor, neurological andneurobehavioral function in very preterm infants.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofpagefrom74
dc.relation.ispartofpageto82
dc.relation.ispartofjournalEarly Human Development
dc.relation.ispartofvolume117
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3213
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320299
dc.subject.fieldofresearchcode5204
dc.titleRelationship between very early brain structure and neuromotor, neurological and neurobehavioral function in infants born <31&#8239;weeks gestational age
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWare, Robert


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