dc.contributor.author | George, Joanne M | |
dc.contributor.author | Fiori, Simona | |
dc.contributor.author | Fripp, Jurgen | |
dc.contributor.author | Pannek, Kerstin | |
dc.contributor.author | Guzzetta, Andrea | |
dc.contributor.author | David, Michael | |
dc.contributor.author | Ware, Robert S | |
dc.contributor.author | Rose, Stephen E | |
dc.contributor.author | Colditz, Paul B | |
dc.contributor.author | Boyd, Roslyn N | |
dc.date.accessioned | 2019-05-29T13:05:08Z | |
dc.date.available | 2019-05-29T13:05:08Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0378-3782 | |
dc.identifier.doi | 10.1016/j.earlhumdev.2017.12.014 | |
dc.identifier.uri | http://hdl.handle.net/10072/379972 | |
dc.description.abstract | Aim: This study aimed to examine associations between structural MRI and concurrent motor, neurological andneurobehavioral measures at 30–32 weeks postmenstrual age (PMA; ‘Early’), and at term equivalent age(‘Term’).Method: In this prospective cohort study, infants underwent Early MRI (n = 119; 73 male; median 32 weeks1 day PMA) and Term MRI (n = 102; 61 male; median 40 weeks 4 days PMA) at 3 T. Structural images werescored generating white matter (WM), cortical gray matter, deep gray matter, cerebellar and global brain ab-normality scores. Clinical measures were General Movements Assessment (GMs), Hammersmith NeonatalNeurological Examination (HNNE) and NICU Neonatal Neurobehavioral Scale (NNNS). The Premie-Neuro wasadministered Early and the Test of Infant Motor Performance (TIMP) and a visual assessment at Term.Results: Early MRI cerebellar scores were strongly associated with neurological components of HNNE (reflexes),NNNS (Hypertonicity), the Premie-Neuro neurological subscale (regression coefficient β = −0.06; 95% con-fidence interval CI = −0.09, −0.04; p < .001) and cramped-synchronized GMs (β = 1.10; 95%CI = 0.57,1.63; p < .001). Term MRI WM and global scores were strongly associated with the TIMP (WM β = −1.02;95%CI = −1.67, −0.36; p = .002; global β = −1.59; 95%CI = −2.62, −0.56; p = .001).Interpretation: Brain structure on Early and Term MRI was associated with concurrent motor, neurological andneurobehavioral function in very preterm infants. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Ireland | |
dc.relation.ispartofpagefrom | 74 | |
dc.relation.ispartofpageto | 82 | |
dc.relation.ispartofjournal | Early Human Development | |
dc.relation.ispartofvolume | 117 | |
dc.subject.fieldofresearch | Paediatrics | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Clinical sciences not elsewhere classified | |
dc.subject.fieldofresearch | Cognitive and computational psychology | |
dc.subject.fieldofresearchcode | 3213 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 320299 | |
dc.subject.fieldofresearchcode | 5204 | |
dc.title | Relationship between very early brain structure and neuromotor, neurological and neurobehavioral function in infants born <31 weeks gestational age | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Ware, Robert | |