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dc.contributor.authorA. Lidbury, Bretten_US
dc.contributor.authorE. Rulli, Nestoren_US
dc.contributor.authorSuhrbier, Andreasen_US
dc.contributor.authorN. Smith, Paulen_US
dc.contributor.authorR. McColl, Shaunen_US
dc.contributor.authorL. Cunningham, Anthonyen_US
dc.contributor.authorTarkowski, Andrejen_US
dc.contributor.authorvan Rooijen, Nicoen_US
dc.contributor.authorJ. Fraser, Roberten_US
dc.contributor.authorMahalingam, Sureshen_US
dc.contributor.editorMartin Hirschen_US
dc.date.accessioned2017-04-24T13:35:35Z
dc.date.available2017-04-24T13:35:35Z
dc.date.issued2008en_US
dc.date.modified2011-04-07T05:32:07Z
dc.identifier.issn00221899en_US
dc.identifier.doi10.1086/587841en_AU
dc.identifier.urihttp://hdl.handle.net/10072/38004
dc.description.abstractAlphaviruses, such as chikungunya virus and Ross River virus (RRV), are associated with outbreaks of infectious rheumatic disease in humans worldwide. Using an established mouse model of disease that mimicsRRVdisease in humans, we showed that macrophage-derived factors are critical in the development of striated muscle and joint tissue damage. Histologic analyses of muscle and ankle joint tissues demonstrated a substantial reduction in inflammatory infiltrates in infected mice depleted of macrophages (i.e., "macrophage-depleted mice"). Levels of the proinflammatory factors tumor necrosis factor-a, interferon-?, and macrophage chemoattractant protein-1 were also dramatically reduced in tissue samples obtained from infected macrophage-depleted mice, compared with samples obtained from infected mice without macrophage depletion. These factors were also detected in the synovial fluid of patients with RRV-induced polyarthritis. Neutralization of these factors reduced the severity of disease in mice, whereas blocking nuclear factor ?B by treatment with sulfasalazine ameliorated RRV inflammatory disease and tissue damage. To our knowledge, these findings are the first to demonstrate that macrophage-derived products play important roles in the development of arthritis and myositis triggered by alphavirus infection.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherOxford University Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1585en_US
dc.relation.ispartofpageto1593en_US
dc.relation.ispartofissue11en_US
dc.relation.ispartofjournalJournal of Infectious Diseasesen_US
dc.relation.ispartofvolume197en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMedical Virologyen_US
dc.subject.fieldofresearchcode110804en_US
dc.titleMacrophage-Derived Proinflammatory Factors Contribute to the Development of Arthritis and Myositis after Infection with an Arthrogenic Alpohavirusen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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