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  • Design and evaluation of novel liposome-based peptide vaccines for improved efficacy against group A streptococcal infections of the mucosa and skin 

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    Ozberk,Victoria _Final Thesis_redacted.pdf (4.414Mb)
    Author(s)
    Pandey, Manisha
    Primary Supervisor
    Good, Michael
    Pandey, Manisha
    Other Supervisors
    Batzloff, Michael
    Year published
    2018
    Metadata
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    Abstract
    Streptococcus pyogenes (group A streptococcus, GAS) is an important human pathogen that is responsible for a range of diseases. Non-invasive diseases include pharyngitis, scarlet fever and pyoderma/impetigo. GAS is also capable of causing invasive diseases such as streptococcal toxic shock syndrome and necrotizing fasciitis. There is a high chance of mortality associated with GAS invasive diseases, with approximately 8-23% of patients dying within 7 days of infection. Consecutive GAS infections may give rise to auto-immune complications, including acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Approximately ...
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    Streptococcus pyogenes (group A streptococcus, GAS) is an important human pathogen that is responsible for a range of diseases. Non-invasive diseases include pharyngitis, scarlet fever and pyoderma/impetigo. GAS is also capable of causing invasive diseases such as streptococcal toxic shock syndrome and necrotizing fasciitis. There is a high chance of mortality associated with GAS invasive diseases, with approximately 8-23% of patients dying within 7 days of infection. Consecutive GAS infections may give rise to auto-immune complications, including acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Approximately 2-3% of patients who acquire streptococcal pharyngitis develop ARF. Skin-associated GAS strains have also been linked to cases of ARF. A vaccine that can stop the progression of disease from the primary sites of infection (URT and skin) is desperately needed.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    Institute for Glycomics
    DOI
    https://doi.org/10.25904/1912/294
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Subject
    Medical and Health Sciences
    Peptide vaccines
    Streptococcal infections
    Liposomal-based delivery systems
    Mucosal vaccine platform
    Skin-infection
    Publication URI
    http://hdl.handle.net/10072/380063
    Collection
    • Theses - Higher Degree by Research

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