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dc.contributor.authorS. Richards, Jacken_US
dc.contributor.authorI. Stanisic, Danielleen_US
dc.contributor.authorJ. I. Fowkes, Freyaen_US
dc.contributor.authorTavul, Livingstoneen_US
dc.contributor.authorDabod, Elijahen_US
dc.contributor.authorK. Thompson, Jenniferen_US
dc.contributor.authorKumar, Sanjeeven_US
dc.contributor.authorE. Chitnis, Chetanen_US
dc.contributor.authorL. Narum, Daviden_US
dc.contributor.authorMichon, Pascalen_US
dc.contributor.authorM. Siba, Peteren_US
dc.contributor.authorF. Cowman, Alanen_US
dc.contributor.authorMueller, Ivoen_US
dc.contributor.authorG. Beeson, Jamesen_US
dc.description.abstractBackground. Antibodies targeting blood stage antigens are important in protection against malaria, but the principle targets remain unclear. Erythrocyte-binding antigens (EBAs) are important erythrocyte invasion ligands used by merozoites and may be targets of protective immunity, but there are limited data examining their potential importance. Methods. We examined antibodies among 206 Papua New Guinean children who were treated with antimalarials at enrolment and observed prospectively for 6 months for reinfection and malaria. Immunoglobulin (Ig) G, IgG subclasses, and IgM to different regions of EBA175, EBA140, and EBA181 expressed as recombinant proteins were assessed in comparison with several other merozoite antigens. Results. High levels of IgG to each of the EBAs were strongly associated with protection from symptomatic malaria and high density parasitemia, but not with risk of reinfection per se. The predominant IgG subclasses were either IgG1 or IgG3, depending on the antigen. The predominance of IgG1 versus IgG3 reflected structural features of specific regions of the proteins. IgG3 was most strongly associated with protection, even for those antigens that had an IgG1 predominant response. Conclusions. The EBAs appear important targets of acquired protective immunity. These findings support their further development as vaccine candidates.en_US
dc.publisherOxford University Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofjournalClinical Infectious Diseasesen_US
dc.subject.fieldofresearchHumoural Immunology and Immunochemistryen_US
dc.titleAssociation between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemiaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text

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