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dc.contributor.authorPinzon-Charry, Albertoen_US
dc.contributor.authorMcPhun, Virginiaen_US
dc.contributor.authorKienzle, Vivianen_US
dc.contributor.authorHirunpetcharat, Chakriten_US
dc.contributor.authorEngwerda, Christianen_US
dc.contributor.authorMcCarthy, Jamesen_US
dc.contributor.authorF. Good, Michaelen_US
dc.date.accessioned2017-04-24T12:31:09Z
dc.date.available2017-04-24T12:31:09Z
dc.date.issued2010en_US
dc.date.modified2011-04-07T05:32:29Z
dc.identifier.issn00219738en_US
dc.identifier.doi10.1172/JCI39222en_AU
dc.identifier.urihttp://hdl.handle.net/10072/38010
dc.description.abstractDevelopment of a vaccine that targets blood-stage malaria parasites is imperative if we are to sustainably reduce the morbidity and mortality caused by this infection. Such a vaccine should elicit long-lasting immune responses against conserved determinants in the parasite population. Most blood-stage vaccines, however, induce protective antibodies against surface antigens, which tend to be polymorphic. Cell-mediated responses, on the other hand, offer the theoretical advantage of targeting internal antigens that are more likely to be conserved. Nonetheless, few of the current blood-stage vaccine candidates are able to harness vigorous T cell immunity. Here, we present what we believe to be a novel blood-stage whole-organism vaccine that, by combining low doses of killed parasite with CpG-oligodeoxynucleotide (CpG-ODN) adjuvant, was able to elicit strong and cross-reactive T cell responses in mice. Our data demonstrate that immunization of mice with 1,000 killed parasites in CpG-ODN engendered durable and cross-strain protection by inducing a vigorous response that was dependent on CD4+ T cells, IFN-gamma, and nitric oxide. If applicable to humans, this approach should facilitate the generation of robust, cross-reactive T cell responses against malaria as well as antigen availability for vaccine manufactureen_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican Society for Clinical Investigationen_US
dc.publisher.placeAmericaen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom2967en_US
dc.relation.ispartofpageto2978en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalJournal of Clinical Investigationen_US
dc.relation.ispartofvolume120en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchInfectious Diseasesen_US
dc.subject.fieldofresearchcode110309en_US
dc.titleLow doses of killed parasite in CpG elicit vigorous CD4+T cell responses against blood-stage malaria in miceen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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