Show simple item record

dc.contributor.authorGood, Michael F
dc.contributor.authorMiller, Louis H
dc.date.accessioned2019-05-29T13:05:58Z
dc.date.available2019-05-29T13:05:58Z
dc.date.issued2018
dc.identifier.issn1476-0584
dc.identifier.doi10.1080/14760584.2018.1435278
dc.identifier.urihttp://hdl.handle.net/10072/380124
dc.description.abstractIntroduction: As the quest for an effective blood stage malaria vaccine continues, there is increasing reliance on the use of controlled human malaria infections (CHMI) in non-endemic settings to test vaccine efficacy at the earliest possible time. This is seen as a way to accelerate vaccine research and quickly eliminate candidates with poor efficacy. Areas covered: The data from these studies need to be carefully examined and interpreted in light of the very different roles that antibody and cellular immunity play in protection and within the context of the distinct clinical sensitivities of volunteers living in malaria-non-endemic countries compared to those living in endemic countries. With current strategies, it is likely that vaccines with protective immunological ‘signatures’ will be missed and potentially good candidates discarded. Expert commentary: Efficacy data from early phase vaccine trials in non-endemic countries should not be used to decide whether or not to proceed to vaccine trials in endemic countries.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherTaylor & Francis
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom189
dc.relation.ispartofpageto196
dc.relation.ispartofissue3
dc.relation.ispartofjournalExpert Review of Vaccines
dc.relation.ispartofvolume17
dc.subject.fieldofresearchPublic Health and Health Services not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode111799
dc.subject.fieldofresearchcode1103
dc.titleInterpreting challenge data from early phase malaria blood stage vaccine trials
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record