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dc.contributor.authorC. Steer, Andrewen_US
dc.contributor.authorW. Jenney, Adamen_US
dc.contributor.authorKado, Josephen_US
dc.contributor.authorF. Good, Michaelen_US
dc.contributor.authorBatzloff, Michaelen_US
dc.contributor.authorMagor, Grahamen_US
dc.contributor.authorMullholland, Kimen_US
dc.contributor.authorRitika, Roselynen_US
dc.contributor.authorR. Carapetis, Jonathanen_US
dc.date.accessioned2017-04-24T08:44:54Z
dc.date.available2017-04-24T08:44:54Z
dc.date.issued2009en_US
dc.date.modified2011-04-07T05:32:33Z
dc.identifier.issn08913668en_US
dc.identifier.doi10.1097/INF.0b013e318194b2afen_AU
dc.identifier.urihttp://hdl.handle.net/10072/38012
dc.description.abstractBackground: Acute rheumatic fever and rheumatic heart disease cause a high burden of disease in Fiji and surrounding Pacific Island countries, but little is known about the epidemiology of group A streptococcal (GAS) pharyngitis in the region. We designed a study to estimate the prevalence of carriage of beta-hemolytic streptococci (BHS) and the incidence of BHS culture-positive sore throat in school aged children in Fiji. Methods: We conducted twice-weekly prospective surveillance of school children aged 5 to 14 years in 4 schools in Fiji during a 9-month period in 2006, after an initial phase of pharyngeal swabbing to determine the prevalence of BHS carriage. Results: We enrolled 685 children. The prevalence of GAS carriage was 6.0%, while the prevalence of group C streptococcal (GCS) and group G streptococcal (GGS) carriage was 6.9% and 12%, respectively. There were 61 episodes of GAS culture-positive sore throat during the study period equating to an incidence of 14.7 cases per 100 child-years (95% CI, 11.2-18.8). The incidence of GCS/GGS culture-positive sore throat was 28.8 cases per 100 child-years (95% CI, 23.9-34.5). The clinical nature of GAS culture-positive sore throat was more severe than culture-negative sore throat, but overall was mild compared with that found in previous studies. Of the 101 GAS isolates that emm sequence typed there were 45 emm types with no dominant types. There were very few emm types commonly encountered in industrialized nations and only 9 of the 45 emm types found in this study are emm types included in the 26-valent GAS vaccine undergoing clinical trials. Conclusions: GAS culture-positive sore throat was more common than expected. Group C and group G streptococci were frequently isolated in throat cultures, although their contribution to pharyngeal infection is not clear. The molecular epidemiology of pharyngeal GAS in our study differed greatly from that in industrialized nations and this has implications for GAS vaccine clinical research in Fiji and other tropical developing countries.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherLippincott Williams & Wilkinsen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom477en_US
dc.relation.ispartofpageto482en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalPediatric Infectious Disease Journalen_US
dc.relation.ispartofvolume28en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchInfectious Diseasesen_US
dc.subject.fieldofresearchcode110309en_US
dc.titleProspective surveillance of streptococcal sore throat in a tropical countryen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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