Algorithm for the Automated Evaluation of NAT2 Genotypes
Author(s)
Michael, Georg
Thier, Ricarda
Blaszkewicz, Meinolf
Selinski, Silvia
Golka, Klaus
Griffith University Author(s)
Year published
2018
Metadata
Show full item recordAbstract
N-Acetyltransferase 2 (NAT2) genotyping by PCR and RFLP-based methods provides information on seven single nucleotide polymorphisms (SNPs) without deriving the chromosomal phase (haplotype). So genotyping results must be processed to get all possible NAT2 haplotype (or allele) combinations. Here we describe the procedure for genotyping and present a program based on Microsoft® Access® which automatically generates all possible haplotype pairs for a given unphased NAT2 genotype. NAT2 haplotypes are important to predict the NAT2 phenotype.N-Acetyltransferase 2 (NAT2) genotyping by PCR and RFLP-based methods provides information on seven single nucleotide polymorphisms (SNPs) without deriving the chromosomal phase (haplotype). So genotyping results must be processed to get all possible NAT2 haplotype (or allele) combinations. Here we describe the procedure for genotyping and present a program based on Microsoft® Access® which automatically generates all possible haplotype pairs for a given unphased NAT2 genotype. NAT2 haplotypes are important to predict the NAT2 phenotype.
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Book Title
Urothelial Carcinoma: Methods and Protocols
Subject
Medical and Health Sciences not elsewhere classified
Other Chemical Sciences
Biochemistry and Cell Biology