Mitocans: Mitochondrially Targeted Anti-cancer Drugs
Author(s)
Boukalova, Stepana
Rohlenova, Katerina
Rohlena, Jakub
Neuzil, Jiri
Griffith University Author(s)
Year published
2018
Metadata
Show full item recordAbstract
Mitochondria are intriguing organelles that are inherently present in most eukaryotic cells, with notable exceptions. They undertake multiple vital functions in a cell, including energy conversion, metabolite synthesis, regulation of the cellular redox state, production of reactive oxygen species, initiation of apoptosis, and buffering cellular Ca2+. Although aberrant, mitochondria are indispensable in malignant cells for critical involvement in synthesis of vital precursors for a variety of metabolic pathways. Therefore, mitochondria have recently emerged as plausible, as yet underexploited targets for cancer therapy. Here ...
View more >Mitochondria are intriguing organelles that are inherently present in most eukaryotic cells, with notable exceptions. They undertake multiple vital functions in a cell, including energy conversion, metabolite synthesis, regulation of the cellular redox state, production of reactive oxygen species, initiation of apoptosis, and buffering cellular Ca2+. Although aberrant, mitochondria are indispensable in malignant cells for critical involvement in synthesis of vital precursors for a variety of metabolic pathways. Therefore, mitochondria have recently emerged as plausible, as yet underexploited targets for cancer therapy. Here we discuss why mitochondria may be clinically relevant anti-cancer therapeutic modalities and give examples of agents that act via mitochondria that we, collectively, refer to as mitocans. Some of these agents hold a great promise for making it to the ‘bedside’, entering clinical trials.
View less >
View more >Mitochondria are intriguing organelles that are inherently present in most eukaryotic cells, with notable exceptions. They undertake multiple vital functions in a cell, including energy conversion, metabolite synthesis, regulation of the cellular redox state, production of reactive oxygen species, initiation of apoptosis, and buffering cellular Ca2+. Although aberrant, mitochondria are indispensable in malignant cells for critical involvement in synthesis of vital precursors for a variety of metabolic pathways. Therefore, mitochondria have recently emerged as plausible, as yet underexploited targets for cancer therapy. Here we discuss why mitochondria may be clinically relevant anti-cancer therapeutic modalities and give examples of agents that act via mitochondria that we, collectively, refer to as mitocans. Some of these agents hold a great promise for making it to the ‘bedside’, entering clinical trials.
View less >
Book Title
Mitochondrial Biology and Experimental Therapeutics
Subject
Medical and Health Sciences not elsewhere classified
Oncology and Carcinogenesis
Medical Biochemistry and Metabolomics