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  • Mitocans: Mitochondrially Targeted Anti-cancer Drugs

    Author(s)
    Boukalova, Stepana
    Rohlenova, Katerina
    Rohlena, Jakub
    Neuzil, Jiri
    Griffith University Author(s)
    Neuzil, Jiri
    Year published
    2018
    Metadata
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    Abstract
    Mitochondria are intriguing organelles that are inherently present in most eukaryotic cells, with notable exceptions. They undertake multiple vital functions in a cell, including energy conversion, metabolite synthesis, regulation of the cellular redox state, production of reactive oxygen species, initiation of apoptosis, and buffering cellular Ca2+. Although aberrant, mitochondria are indispensable in malignant cells for critical involvement in synthesis of vital precursors for a variety of metabolic pathways. Therefore, mitochondria have recently emerged as plausible, as yet underexploited targets for cancer therapy. Here ...
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    Mitochondria are intriguing organelles that are inherently present in most eukaryotic cells, with notable exceptions. They undertake multiple vital functions in a cell, including energy conversion, metabolite synthesis, regulation of the cellular redox state, production of reactive oxygen species, initiation of apoptosis, and buffering cellular Ca2+. Although aberrant, mitochondria are indispensable in malignant cells for critical involvement in synthesis of vital precursors for a variety of metabolic pathways. Therefore, mitochondria have recently emerged as plausible, as yet underexploited targets for cancer therapy. Here we discuss why mitochondria may be clinically relevant anti-cancer therapeutic modalities and give examples of agents that act via mitochondria that we, collectively, refer to as mitocans. Some of these agents hold a great promise for making it to the ‘bedside’, entering clinical trials.
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    Book Title
    Mitochondrial Biology and Experimental Therapeutics
    DOI
    https://doi.org/10.1007/978-3-319-73344-9_27
    Subject
    Medical and Health Sciences not elsewhere classified
    Oncology and Carcinogenesis
    Medical Biochemistry and Metabolomics
    Publication URI
    http://hdl.handle.net/10072/380150
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