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dc.contributor.authorBoukalova, Stepana
dc.contributor.authorRohlenova, Katerina
dc.contributor.authorRohlena, Jakub
dc.contributor.authorNeuzil, Jiri
dc.contributor.editorPaulo J. Oliveira
dc.date.accessioned2019-05-29T13:03:11Z
dc.date.available2019-05-29T13:03:11Z
dc.date.issued2018
dc.identifier.isbn9783319733432
dc.identifier.doi10.1007/978-3-319-73344-9_27
dc.identifier.urihttp://hdl.handle.net/10072/380150
dc.description.abstractMitochondria are intriguing organelles that are inherently present in most eukaryotic cells, with notable exceptions. They undertake multiple vital functions in a cell, including energy conversion, metabolite synthesis, regulation of the cellular redox state, production of reactive oxygen species, initiation of apoptosis, and buffering cellular Ca2+. Although aberrant, mitochondria are indispensable in malignant cells for critical involvement in synthesis of vital precursors for a variety of metabolic pathways. Therefore, mitochondria have recently emerged as plausible, as yet underexploited targets for cancer therapy. Here we discuss why mitochondria may be clinically relevant anti-cancer therapeutic modalities and give examples of agents that act via mitochondria that we, collectively, refer to as mitocans. Some of these agents hold a great promise for making it to the ‘bedside’, entering clinical trials.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer International Publishing AG
dc.publisher.placeSwitzerland
dc.relation.ispartofbooktitleMitochondrial Biology and Experimental Therapeutics
dc.relation.ispartofchapter27
dc.relation.ispartofchapternumbers29
dc.relation.ispartofpagefrom613
dc.relation.ispartofpageto635
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1112
dc.subject.fieldofresearchcode1101
dc.titleMitocans: Mitochondrially Targeted Anti-cancer Drugs
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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