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dc.contributor.authorGuan, Guangzhao
dc.contributor.authorBakr, Mahmoud M
dc.contributor.authorFirth, Norman
dc.contributor.authorLove, Robert M
dc.date.accessioned2019-07-04T12:31:15Z
dc.date.available2019-07-04T12:31:15Z
dc.date.issued2018
dc.identifier.issn2212-4403
dc.identifier.doi10.1016/j.oooo.2018.01.015
dc.identifier.urihttp://hdl.handle.net/10072/380185
dc.description.abstractObjectives. The aim of this study was to identify an association or link between cyclin D1 and p27KIP1protein expression anddysplastic changes or progression.Study Design. Oral mucosal biopsies with a diagnosis of non-neoplastic tissue (gingivitis) (n = 10), mild to moderate oral epi-thelial dysplasia (n = 12), and oral squamous cell carcinoma (n = 11) were evaluated by using immunohistochemistry. Scanningsoftware was used to determine cyclin D1 and p27KIP1intensity of expression, location, and pattern.Results. A significant increase in expression of cyclin D1 and a decrease in expression of p27KIP1proteins were identified in oralepithelial dysplasia and less differentiated oral squamous cell carcinoma (OSCC). There was a more diffuse distribution of cyclinD1 protein expression extending from the basal cell layer into the prickle cell layers in epithelial dysplasia and extending withinall epithelial layers in OSCC. Cases of oral epithelial dysplasia had moderate infrequent expression of p27KIP1. There were nop27KIP1-positiv e cells in OSCC. The percentage of cells with both nuclear and c ytoplasmic cyclin D1 staining was higher in OSCCspecimens than control groups and oral epithelial dysplasia.Conclusions. The expression of both cyclin D1 and p27KIP1correlated with the grade of oral epithelial dysplasia and degree ofOSCC differentiation. The results obtained will be verified through a basic follow-up of the cases to determine the prognosis/progression of oral dysplasia.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofpagefrom174
dc.relation.ispartofpageto183
dc.relation.ispartofissue2
dc.relation.ispartofjournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.relation.ispartofvolume126
dc.subject.fieldofresearchOral medicine and pathology
dc.subject.fieldofresearchTumour immunology
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode320307
dc.subject.fieldofresearchcode320409
dc.subject.fieldofresearchcode3203
dc.titleExpression of cyclin D1 correlates with p27KIP1 and regulates the degree of oral dysplasia and squamous cell carcinoma differentiation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorBakr, Mahmoud


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