dc.contributor.author | Guan, Guangzhao | |
dc.contributor.author | Bakr, Mahmoud M | |
dc.contributor.author | Firth, Norman | |
dc.contributor.author | Love, Robert M | |
dc.date.accessioned | 2019-07-04T12:31:15Z | |
dc.date.available | 2019-07-04T12:31:15Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2212-4403 | |
dc.identifier.doi | 10.1016/j.oooo.2018.01.015 | |
dc.identifier.uri | http://hdl.handle.net/10072/380185 | |
dc.description.abstract | Objectives. The aim of this study was to identify an association or link between cyclin D1 and p27KIP1protein expression anddysplastic changes or progression.Study Design. Oral mucosal biopsies with a diagnosis of non-neoplastic tissue (gingivitis) (n = 10), mild to moderate oral epi-thelial dysplasia (n = 12), and oral squamous cell carcinoma (n = 11) were evaluated by using immunohistochemistry. Scanningsoftware was used to determine cyclin D1 and p27KIP1intensity of expression, location, and pattern.Results. A significant increase in expression of cyclin D1 and a decrease in expression of p27KIP1proteins were identified in oralepithelial dysplasia and less differentiated oral squamous cell carcinoma (OSCC). There was a more diffuse distribution of cyclinD1 protein expression extending from the basal cell layer into the prickle cell layers in epithelial dysplasia and extending withinall epithelial layers in OSCC. Cases of oral epithelial dysplasia had moderate infrequent expression of p27KIP1. There were nop27KIP1-positiv e cells in OSCC. The percentage of cells with both nuclear and c ytoplasmic cyclin D1 staining was higher in OSCCspecimens than control groups and oral epithelial dysplasia.Conclusions. The expression of both cyclin D1 and p27KIP1correlated with the grade of oral epithelial dysplasia and degree ofOSCC differentiation. The results obtained will be verified through a basic follow-up of the cases to determine the prognosis/progression of oral dysplasia. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Netherlands | |
dc.relation.ispartofpagefrom | 174 | |
dc.relation.ispartofpageto | 183 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | |
dc.relation.ispartofvolume | 126 | |
dc.subject.fieldofresearch | Oral medicine and pathology | |
dc.subject.fieldofresearch | Tumour immunology | |
dc.subject.fieldofresearch | Dentistry | |
dc.subject.fieldofresearchcode | 320307 | |
dc.subject.fieldofresearchcode | 320409 | |
dc.subject.fieldofresearchcode | 3203 | |
dc.title | Expression of cyclin D1 correlates with p27KIP1 and regulates the degree of oral dysplasia and squamous cell carcinoma differentiation | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | © 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Bakr, Mahmoud | |