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dc.contributor.authorKarunanithi, Shanker
dc.contributor.authorTroup, Michael
dc.contributor.authorvan Swinderen, Bruno
dc.contributor.editorRoderic G. Eckenhoff, Ivan J. Dmochowski
dc.date.accessioned2019-05-29T13:03:02Z
dc.date.available2019-05-29T13:03:02Z
dc.date.issued2018
dc.identifier.isbn9780128127407
dc.identifier.doi10.1016/bs.mie.2018.02.003
dc.identifier.urihttp://hdl.handle.net/10072/380222
dc.description.abstractInvestigating mechanisms of general anesthesia requires access to multiple levels of neuronal function, from effects at individual synapses to responses in behaving animals. Drosophila melanogaster provides an excellent model to test different theories for general anesthesia because it offers robust methods for testing local as well as global target processes, in an animal that is similarly impacted by these diverse drugs as humans. Here, we outline methods to quantify two such endpoints, neurotransmission and behavioral responsiveness, focusing on the intravenous drug propofol.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofbooktitleMethods in Enzymology
dc.relation.ispartofchapter8
dc.relation.ispartofchapternumbers19
dc.relation.ispartofpagefrom153
dc.relation.ispartofpageto176
dc.relation.ispartofvolume602
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode0601
dc.titleUsing Drosophila to Understand General Anesthesia: From Synapses to Behavior
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorKarunanithi, Shanker


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