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dc.contributor.authorLira-Junior, Ronaldo
dc.contributor.authorFigueredo, Carlos Marcelo
dc.date.accessioned2018-09-03T00:39:37Z
dc.date.available2018-09-03T00:39:37Z
dc.date.issued2016
dc.identifier.issn1007-9327
dc.identifier.doi10.3748/wjg.v22.i35.7963
dc.identifier.urihttp://hdl.handle.net/10072/380233
dc.description.abstractPeriodontal disease and inflammatory bowel disease (IBD) are both chronic inflammatory diseases. Their pathogenesis is mediated by a complex interplay between a dysbiotic microbiota and the host immune-inflammatory response, and both are influenced by genetic and environmental factors. This review aimed to provide an overview of the evidence dealing with a possible pathogenic interaction between periodontal disease and IBD. There seems to be an increased prevalence of periodontal disease in patients with IBD when compared to healthy controls, probably due to changes in the oral microbiota and a higher inflammatory response. Moreover, the induction of periodontitis seems to result in gut dysbiosis and altered gut epithelial cell barrier function, which might contribute to the pathogenesis of IBD. Considering the complexity of both periodontal disease and IBD, it is very challenging to understand the possible pathways involved in their coexistence. In conclusion, this review points to a complex pathogenic interaction between periodontal disease and IBD, in which one disease might alter the composition of the microbiota and increase the inflammatory response related to the other. However, we still need more data derived from human studies to confirm results from murine models. Thus, mechanistic studies are definitely warranted to clarify this possible bidirectional association.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBaishideng Publishing Group
dc.relation.ispartofpagefrom7963
dc.relation.ispartofpageto7972
dc.relation.ispartofissue35
dc.relation.ispartofjournalWorld Journal of Gastroenterology
dc.relation.ispartofvolume22
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPeriodontics
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320310
dc.titlePeriodontal and inflammatory bowel diseases: Is there evidence of complex pathogenic interactions?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by-nc/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
gro.hasfulltextFull Text
gro.griffith.authorda Silva Figueredo, Carlos Marcelo


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