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  • Epidemiological serosurvey of hepatitis B virus among children aged 1-14 years in Guangdong Province, China

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    Author(s)
    Zhu, Qi
    Shao, Xiaoping
    Chen, Shaoli
    Li, Dingliang
    Chen, Xiaohong
    Liu, Wenjin
    Wu, Xianghua
    Jian, Zengyong
    Rutherford, Shannon
    Zheng, Huizhen
    Griffith University Author(s)
    Rutherford, Shannon
    Year published
    2018
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    Abstract
    Objective: A cross-sectional community prevalence survey was conducted to investigate the seroepidemiological features of hepatitis B virus (HBV) infection among children aged 1–14 years in Guangdong Province in 2013, and to provide baseline data for the evaluation of HBV disease burden and the impacts of HBV control. Methods: A total of 2765 children aged 1–14 years from 16 villages/streets of eight cities in Guangdong Province were recruited as subjects. A blood sample was obtained from each subject. A chemiluminescence microparticle immunoassay (CMIA) was used to detect hepatitis B surface antigen (HBsAg), antibody to ...
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    Objective: A cross-sectional community prevalence survey was conducted to investigate the seroepidemiological features of hepatitis B virus (HBV) infection among children aged 1–14 years in Guangdong Province in 2013, and to provide baseline data for the evaluation of HBV disease burden and the impacts of HBV control. Methods: A total of 2765 children aged 1–14 years from 16 villages/streets of eight cities in Guangdong Province were recruited as subjects. A blood sample was obtained from each subject. A chemiluminescence microparticle immunoassay (CMIA) was used to detect hepatitis B surface antigen (HBsAg), antibody to hepatitis B surface antigen (HBsAb), and antibody to hepatitis B core antigen (HBcAb). Results: The prevalence rates of HBsAg, HBsAb, and HBcAb among children aged 1–14 years were 1.16%, 61.63%, and 2.35%, respectively. The prevalence of HBsAg and HBcAb increased with increasing age, and the prevalence was lowest in the 1–4 years age group (0.97% for HBsAg and 1.45% for HBcAb). In contrast, the prevalence of HBsAb decreased with increasing age; however the prevalence was also highest in the 1–4 years age group (76.48%). Eastern Guangdong had the highest prevalence of HBsAg and HBcAb, and the lowest prevalence of HBsAb. The prevalence of HBsAg was under 1% in the Pearl River Delta and western Guangdong regions. Children who had received three or more doses of vaccine had a lower prevalence of HBsAg and HBcAb and a higher prevalence of HBsAb compared to those who had received fewer than three doses of vaccine. Conclusions: The prevalence of HBsAg among children aged 1–14 years in Guangdong in 2013 was 1.2%, showing a dramatic decrease compared to the 1992 provincial-level cross-sectional survey (19.9%). Children aged 1–4 years and children from the Pearl River Delta had the lowest prevalence of HBsAg positivity. High vaccination coverage among children and timely vaccination of newborns has played an important role in reducing the prevalence of HBsAg.
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    Journal Title
    International Journal of Infectious Diseases
    Volume
    71
    DOI
    https://doi.org/10.1016/j.ijid.2018.01.027
    Copyright Statement
    © 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Microbiology
    Medical microbiology
    Medical microbiology not elsewhere classified
    Health services and systems
    Public health
    Publication URI
    http://hdl.handle.net/10072/380305
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    • Journal articles

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