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dc.contributor.authorLiao, Sam
dc.contributor.authorNeidlin, Michael
dc.contributor.authorLi, Zhiyong
dc.contributor.authorSimpson, Benjamin
dc.contributor.authorGregory, Shaun D
dc.date.accessioned2019-05-29T12:35:51Z
dc.date.available2019-05-29T12:35:51Z
dc.date.issued2018
dc.identifier.issn0021-9290
dc.identifier.doi10.1016/j.jbiomech.2018.02.038
dc.identifier.urihttp://hdl.handle.net/10072/380368
dc.description.abstractLeft ventricular assist devices are associated with thromboembolic events, which are potentially caused by altered intraventricular flow. Due to patient variability, differences in apical wall thickness affects cannula insertion lengths, potentially promoting unfavourable intraventricular flow patterns which are thought to be correlated to the risk of thrombosis. This study aimed to present a 3D multiscale computational fluid dynamic model of the left ventricle (LV) developed using a commercial software, Ansys, and evaluate the risk of thrombosis with varying inflow cannula insertion lengths in a severely dilated LV. Based on a HeartWare HVAD inflow cannula, insertion lengths of 5, 19, 24 and 50 mm represented cases of apical hypertrophy, typical ranges of apical thicknesses and an experimental length, respectively. The risk of thrombosis was evaluated based on blood washout, residence time, instantaneous blood stagnation and a pulsatility index. By introducing fresh blood to displace pre-existing blood in the LV, after 5 cardiac cycles, 46.7%, 45.7%, 45.1% and 41.8% of pre-existing blood remained for insertion lengths of 5, 19, 24 and 50 mm, respectively. Compared to the 50 mm insertion, blood residence time was at least 9%, 7% and 6% higher with the 5, 19 and 24 mm insertion lengths, respectively. No instantaneous stagnation at the apex was observed directly after the E-wave. Pulsatility indices adjacent to the cannula increased with shorter insertion lengths. For the specific scenario studied, a longer insertion length, relative to LV size, may be advantageous to minimise thrombosis by increasing LV washout and reducing blood residence time.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom106
dc.relation.ispartofpageto115
dc.relation.ispartofjournalJournal of Biomechanics
dc.relation.ispartofvolume72
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchHuman Movement and Sports Sciences
dc.subject.fieldofresearchMechanical Engineering
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode1106
dc.subject.fieldofresearchcode0913
dc.titleVentricular flow dynamics with varying LVAD inflow cannula lengths: In-silico evaluation in a multiscale model
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionPost-print
gro.rights.copyright© 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorGregory, Shaun D.


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