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dc.contributor.authorCock, Ian
dc.contributor.authorCheesman, Matthew
dc.contributor.editorMegh R. Goyal, PhD Ademola O. Ayeleso
dc.date.accessioned2019-05-29T13:06:30Z
dc.date.available2019-05-29T13:06:30Z
dc.date.issued2019
dc.identifier.isbn9781771886482
dc.identifier.doi10.1201/b22426
dc.identifier.urihttp://hdl.handle.net/10072/380421
dc.description.abstractPlants have been used as therapeutic agents since the start of civilization. In many developing countries, herbal medicinal systems remain important in the treatment of many ailments. Ayuvedic medicine is still commonly practiced within India with an estimated 85% of Indians still using crude plant preparations for the treatment of wide variety of diseases and ailments [79]. Traditional Chinese medicine (TCM) and African medicinal systems also account for major portion of healthcare in their populations. Even in countries where allopathic/Western medicine is dominant, medicinal plants still make significant contributions. Furthermore, many people are returning to herbal medicine systems due to the perception that natural medicines are often a safer alternative than allopathic drugs. Individuals are also seeking treatments for diseases, which have not yet been remedied by modern medicine. Many of the prescription drugs currently marketed for a wide variety of ailments were originally isolated from plants and/or are semi-synthetic analogues of phytochemicals. It has been estimated that approximately 25% of all prescription drugs currently in use are of plant origin [122, 194]. Furthermore, 75% of new anticancer drugs marketed between 1981 and 2006 were derived from plant compounds [122]. Traditional plant-based medicines are generally used as crude formulations (e.g., infusions, tinctures and extracts, essential oils, powders, poultices, and other herbal preparations). Modern natural product drug discovery generally focuses on isolating and characterizing the individual phytochemical components with the aim of producing an analogue with increased bioactivity/bioavailability. Such studies have given rise to many useful drugs such as quinine (from Cinchona spp.), digoxin (from Digitalis spp.) as well as the anticancer drug paclitaxel (from Taxus brevifolia Nutt.) and vincristine and vinblastine (from Vinca rosea). However, the bioactivities observed for crude extracts are often much enhanced or even entirely different to those seen for the individual components [32, 81]. Crude plant extracts may contain hundreds, or even thousands, of different chemical constituents that interact in complex ways. Often it is not known how an extract works, even when its therapeutic benefit is well established. Thus, phytochemical and mechanistic studies of traditional medicines may be complex, and it is often difficult to assign single compound/bioactivity relationship.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherApple Academic Press
dc.publisher.placeUnited States
dc.publisher.urihttp://www.appleacademicpress.com/bioactive-compounds-of-medicinal-plants-properties-and-potential-for-human-health/9781771886482
dc.relation.ispartofbooktitleBioactive Compounds of Medicinal Plants: Properties and Potential for Human Health
dc.relation.ispartofchapter3
dc.relation.ispartofchapternumbers12
dc.relation.ispartofpagefrom35
dc.relation.ispartofpageto84
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchcode119999
dc.titlePlants of the genus Syzygium (Myrtaceae): A review on ethnobotany, medicinal properties and phytochemistry
dc.typeBook chapter
dc.type.descriptionB2 - Chapters (Other)
dc.type.codeB - Book Chapters
dc.description.versionAccepted Manuscript (AM)
gro.facultyGriffith Sciences, School of Environment and Science
gro.rights.copyrightCourtesy of Apple Academic Press from Bioactive Compounds of Medicinal Plants: Properties and Potential for Human Health. © 2018. http://www.appleacademicpress.com/bioactive-compounds-of-medicinal-plants-properties-and-potential-for-human-health/9781771886482
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.
gro.griffith.authorCheesman, Matthew


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