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  • Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca

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    Davis73338-Accepted.pdf (467.3Kb)
    File version
    Accepted Manuscript (AM)
    Author(s)
    Kumar, Rohitesh
    Duffy, Sandra
    Avery, Vicky M
    Carroll, Anthony R
    Davis, Rohan A
    Griffith University Author(s)
    Davis, Rohan A.
    Carroll, Anthony R.
    Duffy, Sandra
    Avery, Vicky M.
    Kumar, Rohitesh
    Year published
    2018
    Metadata
    Show full item record
    Abstract
    Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline–serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 μM. Microthecaline A represents the first quinoline–serrulatane alkaloid to be isolated from Nature.Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline–serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 μM. Microthecaline A represents the first quinoline–serrulatane alkaloid to be isolated from Nature.
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    Journal Title
    Journal of Natural Products
    Volume
    81
    Issue
    4
    DOI
    https://doi.org/10.1021/acs.jnatprod.7b00992
    Copyright Statement
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright 2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jnatprod.7b00992
    Subject
    Chemical sciences
    Biological sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/380535
    Collection
    • Journal articles

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