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dc.contributor.authorAbdal-Ha, Abdalla
dc.contributor.authorHamlet, Stephen
dc.contributor.authorIvanovski, Saso
dc.date.accessioned2019-05-29T12:37:12Z
dc.date.available2019-05-29T12:37:12Z
dc.date.issued2019
dc.identifier.issn1758-5082
dc.identifier.doi10.1088/1758-5090/aae421
dc.identifier.urihttp://hdl.handle.net/10072/380663
dc.description.abstractNanoscale fibers mimicking the extracellular matrix of natural tissue can be produced by conventional electrospinning, but this approach results in two-dimensional thin dense fibrous mats which can hinder effective cell infiltration. The aim of the present study was to design a thick, three-dimensional (3D) cylindrical scaffold with an open pore structure assembled from short polycaprolactone (PCL) fibers using a facile airbrushing approach. In addition, magnesium-particles were incorporated into the PCL solution to both enhance the mechanical properties of the scaffold and stimulate cellular activity following cell seeding. Separated short composite airbrushed fibers were assembled into a 3D cylindrical structure by cold-press molding and thermal crosslinking. The microstructure, chemical composition, porosity and thermal properties were subsequently investigated, along with changes in mechanical performance following immersion in PBS for 60 days. The results showed that the assembled 3D fibrous 10 mm thick cylindrical matrix had an interconnected fibrous network structure with 31.5-60 % porosity. Encapsulation of the Mg particles into the 3D assembled fibrous scaffold enhanced the mechanical properties of the plain PCL scaffolds. The results also demonstrated controlled release of Mg ions into the PBS media for up to 60 days, as evaluated by changes in Mg ion concentration and pH of the media. In addition, the 3D fibrous assembled matrix was shown to support human osteoblast-like cell adhesion, proliferation and penetration. The results suggest that this novel fabrication method of biodegradable thick 3D scaffolds with an open pore structure is promising for the production of a new generation of 3D scaffolds for tissue regeneration applications. 
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherInstitute of Physics Publishing
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto41
dc.relation.ispartofjournalBiofabrication
dc.subject.fieldofresearchRegenerative Medicine (incl. Stem Cells and Tissue Engineering)
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchMedical Biotechnology
dc.subject.fieldofresearchOther Technology
dc.subject.fieldofresearchcode100404
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode1004
dc.subject.fieldofresearchcode1099
dc.titleFabrication of a Thick Three-Dimensional Scaffold with an Open Cellular-Like Structure Using Airbrushing and Thermal Cross-Linking of Molded Short Nanofibers
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.description.versionPost-print
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2018 IOP Publishing Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorHamlet, Stephen
gro.griffith.authorIvanovski, Saso


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