Fabrication and properties of L-arginine-doped PCL electrospun composite scaffolds

Abstract

The article describes fabrication and properties of composite fibrous scaffolds obtained by electrospinning of the solution of poly(ε-caprolactone) and arginine in hexafluoro-2-propanol for the first time. The influence of arginine content on structure, mechanical, surface and biological properties of the scaffolds was investigated. It was found that arginine addition reduces diameter of the scaffold fibers and doesn’t impair mechanical properties of the polymer. Porosity and water contact angle of the scaffold were independent from arginine content. The best adhesion and viability of multipotent mesenchymal stem cells was shown on scaffolds with arginine concentration from 0.5 to 1% wt.