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dc.contributor.authorChan, Jonathan
dc.contributor.authorEdwards, Natalie FA
dc.contributor.authorKhandheria, Bijoy K
dc.contributor.authorShiino, Kenji
dc.contributor.authorSabapathy, Surendran
dc.contributor.authorAnderson, Bonita
dc.contributor.authorChamberlain, Robert
dc.contributor.authorScalia, Gregory M
dc.date.accessioned2019-06-08T01:31:02Z
dc.date.available2019-06-08T01:31:02Z
dc.date.issued2019
dc.identifier.issn2047-2404
dc.identifier.doi10.1093/ehjci/jey131
dc.identifier.urihttp://hdl.handle.net/10072/380751
dc.description.abstractAims: Non-invasive left ventricular (LV) pressure–strain loop (PSL) provides a novel method of quantifying myocardial work (MW) with potential advantages over conventional global longitudinal strain (GLS) by incorporating measurements of myocardial deformation and LV pressure. We investigated different patterns of LV PSL and global MW index (GWI) in patients with hypertension (HTN) and dilated cardiomyopathy (CMP). Methods and results: Seventy-four patients underwent transthoracic echocardiography and strain analysis before coronary angiography. Patients were divided into three groups: control, HTN, and CMP. GWI was calculated as the area of the LV PSL as a product of strain × systolic blood pressure. MW efficiency (GWE) is derived from the percentage ratio of constructive work (GCW) to sum of constructive work (GCW) and wasted work (GWW). Influences of HTN and LV function on its relationship with MW were evaluated. GLS and LV ejection fraction were preserved in the HTN group with no difference from controls. GWI was significantly higher in moderate to severe HTN patients (P = 0.004) as a compensatory mechanism to preserve LV contractility and function against an increase in afterload. GWE was preserved in HTN patients due to the proportional increase in GCW and GWW. GLS, GWI, and GWE were significantly reduced in CMP (P < 0.05), with a trend in rightward shift and reduction in the LV PSL. Conclusion: GWI is a potential new technique that allows better understanding of the relationship between LV remodelling and increased wall stress under different loading conditions.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom31
dc.relation.ispartofpageto39
dc.relation.ispartofissue1
dc.relation.ispartofjournalEuropean Heart Journal Cardiovascular Imaging
dc.relation.ispartofvolume20
dc.subject.fieldofresearchCardiology (incl. cardiovascular diseases)
dc.subject.fieldofresearchcode320101
dc.titleA new approach to assess myocardial work by non-invasive left ventricular pressure-strain relations in hypertension and dilated cardiomyopathy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorSabapathy, Surendran
gro.griffith.authorEdwards, Natalie
gro.griffith.authorChan, Jonathan H.


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