dc.contributor.author | Balmain, Bryce N | |
dc.contributor.author | Jay, Ollie | |
dc.contributor.author | Morris, Norman R | |
dc.contributor.author | Stewart, Glenn M | |
dc.contributor.author | Shiino, Kenji | |
dc.contributor.author | McFarland, Amelia J | |
dc.contributor.author | Jayasinghe, Rohan | |
dc.contributor.author | Chan, Jonathan | |
dc.contributor.author | Sabapathy, Surendran | |
dc.date.accessioned | 2019-05-29T12:37:28Z | |
dc.date.available | 2019-05-29T12:37:28Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0363-6119 | |
dc.identifier.doi | 10.1152/ajpregu.00132.2018 | |
dc.identifier.uri | http://hdl.handle.net/10072/380753 | |
dc.description.abstract | Heart failure (HF) patients are susceptible to heat strain during exercise, secondary to blunted skin blood flow (SkBF) responses, which may be explained by impaired nitric oxide (NO)-dependent vasodilation. Folic acid improves vascular endothelial function and SkBF through NO-dependent mechanisms in healthy older individuals and patients with cardiovascular disease. We examined the effect of folic acid supplementation (5 mg/day for 6 wk) on vascular function [brachial artery flow-mediated dilation (FMD)] and SkBF responses [cutaneous vascular conductance (CVC)] during 60 min of exercise at a fixed metabolic heat production (300 ẆHprod) in a 30°C environment in 10 patients with HF (New York Heart Association Class I–II) and 10 healthy controls (CON). Serum folic acid concentration increased in HF [preintervention (pre): 1.4 ± 0.2; postintervention (post): 8.9 ± 6.7 ng/ml, P = 0.01] and CON (pre: 1.3 ± 0.6; post: 5.2 ± 4.9 ng/ml, P = 0.03). FMD improved by 2.1 ± 1.3% in HF (P < 0.01), but no change was observed in CON postintervention (P = 0.20). During exercise, the external workload performed on the cycle ergometer to attain the fixed level of heat production for exercise was similar between groups (HF: 60 ± 13; CON: 65 ± 20 external workload, P = 0.52). Increases in CVC during exercise were similar in HF (pre: 0.89 ± 0.43; post: 0.83 ± 0.45 au/mmHg, P = 0.80) and CON (pre: 2.01 ± 0.79; post: 2.03 ± 0.72 au/mmHg, P = 0.73), although the values were consistently lower in HF for both pre- and postintervention measurement intervals (P < 0.05). These findings demonstrate that folic acid improves vascular endothelial function in patients with HF but does not enhance SkBF during exercise at a fixed metabolic heat production in a warm environment. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Physiological Society | |
dc.publisher.place | United States | |
dc.relation.ispartofpagefrom | R810 | |
dc.relation.ispartofpageto | R819 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology | |
dc.relation.ispartofvolume | 315 | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Cardiology (incl. cardiovascular diseases) | |
dc.subject.fieldofresearch | Health sciences | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 320101 | |
dc.subject.fieldofresearchcode | 42 | |
dc.title | Folic acid supplementation improves vascular endothelial function, yet not skin blood flow during exercise in the heat, in patients with heart failure | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dc.description.version | Accepted Manuscript (AM) | |
gro.faculty | Griffith Health, School of Allied Health Sciences | |
gro.rights.copyright | © 2018 American Physiological Society . This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Sabapathy, Surendran | |
gro.griffith.author | Morris, Norman | |
gro.griffith.author | Chan, Jonathan H. | |