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dc.contributor.authorBalmain, Bryce N
dc.contributor.authorJay, Ollie
dc.contributor.authorMorris, Norman R
dc.contributor.authorStewart, Glenn M
dc.contributor.authorShiino, Kenji
dc.contributor.authorMcFarland, Amelia J
dc.contributor.authorJayasinghe, Rohan
dc.contributor.authorChan, Jonathan
dc.contributor.authorSabapathy, Surendran
dc.date.accessioned2019-05-29T12:37:28Z
dc.date.available2019-05-29T12:37:28Z
dc.date.issued2018
dc.identifier.issn0363-6119
dc.identifier.doi10.1152/ajpregu.00132.2018
dc.identifier.urihttp://hdl.handle.net/10072/380753
dc.description.abstractHeart failure (HF) patients are susceptible to heat strain during exercise, secondary to blunted skin blood flow (SkBF) responses, which may be explained by impaired nitric oxide (NO)-dependent vasodilation. Folic acid improves vascular endothelial function and SkBF through NO-dependent mechanisms in healthy older individuals and patients with cardiovascular disease. We examined the effect of folic acid supplementation (5 mg/day for 6 wk) on vascular function [brachial artery flow-mediated dilation (FMD)] and SkBF responses [cutaneous vascular conductance (CVC)] during 60 min of exercise at a fixed metabolic heat production (300 ẆHprod) in a 30°C environment in 10 patients with HF (New York Heart Association Class I–II) and 10 healthy controls (CON). Serum folic acid concentration increased in HF [preintervention (pre): 1.4 ± 0.2; postintervention (post): 8.9 ± 6.7 ng/ml, P = 0.01] and CON (pre: 1.3 ± 0.6; post: 5.2 ± 4.9 ng/ml, P = 0.03). FMD improved by 2.1 ± 1.3% in HF (P < 0.01), but no change was observed in CON postintervention (P = 0.20). During exercise, the external workload performed on the cycle ergometer to attain the fixed level of heat production for exercise was similar between groups (HF: 60 ± 13; CON: 65 ± 20 external workload, P = 0.52). Increases in CVC during exercise were similar in HF (pre: 0.89 ± 0.43; post: 0.83 ± 0.45 au/mmHg, P = 0.80) and CON (pre: 2.01 ± 0.79; post: 2.03 ± 0.72 au/mmHg, P = 0.73), although the values were consistently lower in HF for both pre- and postintervention measurement intervals (P < 0.05). These findings demonstrate that folic acid improves vascular endothelial function in patients with HF but does not enhance SkBF during exercise at a fixed metabolic heat production in a warm environment.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.publisher.placeUnited States
dc.relation.ispartofpagefromR810
dc.relation.ispartofpagetoR819
dc.relation.ispartofissue4
dc.relation.ispartofjournalAmerican Journal of Physiology: Regulatory, Integrative and Comparative Physiology
dc.relation.ispartofvolume315
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchCardiology (incl. cardiovascular diseases)
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320101
dc.subject.fieldofresearchcode42
dc.titleFolic acid supplementation improves vascular endothelial function, yet not skin blood flow during exercise in the heat, in patients with heart failure
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.facultyGriffith Health, School of Allied Health Sciences
gro.rights.copyright© 2018 American Physiological Society . This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorSabapathy, Surendran
gro.griffith.authorMorris, Norman
gro.griffith.authorChan, Jonathan H.


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