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dc.contributor.authorPandey, Manisha
dc.contributor.authorOzberk, Victoria
dc.contributor.authorLangshaw, Emma L
dc.contributor.authorCalcutt, Ainslie
dc.contributor.authorPowell, Jessica
dc.contributor.authorBatzloff, Michael R
dc.contributor.authorRivera-Hernandez, Tania
dc.contributor.authorGood, Michael F
dc.date.accessioned2019-05-29T12:37:48Z
dc.date.available2019-05-29T12:37:48Z
dc.date.issued2018
dc.identifier.issn2059-0105
dc.identifier.doi10.1038/s41541-018-0053-9
dc.identifier.urihttp://hdl.handle.net/10072/380813
dc.description.abstractAntigenic diversity of the M protein is a major constraint to the development of immunity to group A streptococcus (GAS). We demonstrate that a conserved cryptic epitope that is unrecognized by the host immune system following infection can protect mice following vaccination, and that immunity is strengthened and broadened following successive infections. The observation that infection can boost and broaden, but cannot prime immunity to a cryptic epitope, may be exploited for vaccines for other pathogens.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited Kingdom
dc.relation.ispartofchapter15
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto4
dc.relation.ispartofjournalnpj Vaccines
dc.relation.ispartofvolume3
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode320299
dc.subject.fieldofresearchcode3204
dc.subject.fieldofresearchcode3207
dc.titleSkin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.rights.copyright© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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gro.griffith.authorPandey, Manisha
gro.griffith.authorGood, Michael F.
gro.griffith.authorOzberk, Victoria


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