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dc.contributor.authorRuhayel, Rashaen_US
dc.contributor.authorCorry, Benen_US
dc.contributor.authorBraun, Carlosen_US
dc.contributor.authorS. Thomas, Donalden_US
dc.contributor.authorBerners-Price, Sueen_US
dc.contributor.authorFarrell, Nicholasen_US
dc.date.accessioned2017-04-24T08:48:31Z
dc.date.available2017-04-24T08:48:31Z
dc.date.issued2010en_US
dc.date.modified2011-04-08T04:48:10Z
dc.identifier.issn00201669en_US
dc.identifier.doi10.1021/ic100576ken_AU
dc.identifier.urihttp://hdl.handle.net/10072/38083
dc.description.abstractTwo-dimensional (2D) [(1)H, (15)N] heteronuclear single-quantum coherence (HSQC) NMR experiments of the kinetics of aquation and sulfation of the dinuclear platinum anticancer complex [{trans-PtCl(NH(3))(2)}(2)(孎H(2)(CH(2))(6)NH(2))](2+) (1,1/t,t, 1) in 15 mM sulfate solution are reported using conditions (298 K, pH 5.4) identical to those previously used for other anionic systems (phosphate and acetate), allowing for a direct comparison. Sulfate is the fourth most abundant anion in human plasma. The rate constant for the aquation step (k(H)) is higher than that previously found in the presence of phosphate, but the anation rate constants are similar. The rate constant for sulfate displacement of the aqua ligand (k(L)) is approximen_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican Chemical Societyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom10815en_US
dc.relation.ispartofpageto10819en_US
dc.relation.ispartofissue23en_US
dc.relation.ispartofjournalInorganic Chemistryen_US
dc.relation.ispartofvolume49en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBioinorganic Chemistryen_US
dc.subject.fieldofresearchcode030201en_US
dc.titleDetermination of the Kinetic Profile of a Dinuclear Platinum Anticancer Complex in the Presence of Sulfate: Introducing a New Tool for the Expedited Analysis of 2D [1H, 15N] HSQC NMR Spectraen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_AU
gro.date.issued2010
gro.hasfulltextNo Full Text


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