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  • Terminalia ferdinandiana Exell. Fruit and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Cancer Cell Lines

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    Accepted Manuscript (AM)
    Author(s)
    Shalom, Joseph
    Cock, Ian E
    Griffith University Author(s)
    Cock, Ian E.
    Year published
    2018
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    Abstract
    Terminalia spp. are characterized by their high antioxidant contents and several species have anticancer activity. This study examined T. ferdinandiana fruit and leaf extracts for antiproliferative and apoptotic activities against a panel of human carcinoma cell lines. All extracts inhibited Caco2, HeLa, Jeg-3, JAR, MC3T3-E1, and MG63 proliferation. The leaf ethyl acetate extract was the most potent inhibitor of proliferation (MC3T3-E1 IC50 = of 6 µg/ml; Caco2 IC50 = 102 µg/ml). Furthermore, IC50's < 500 µg/ml were determined against all cell lines tested against that extract. The methanolic leaf extract was also a potent ...
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    Terminalia spp. are characterized by their high antioxidant contents and several species have anticancer activity. This study examined T. ferdinandiana fruit and leaf extracts for antiproliferative and apoptotic activities against a panel of human carcinoma cell lines. All extracts inhibited Caco2, HeLa, Jeg-3, JAR, MC3T3-E1, and MG63 proliferation. The leaf ethyl acetate extract was the most potent inhibitor of proliferation (MC3T3-E1 IC50 = of 6 µg/ml; Caco2 IC50 = 102 µg/ml). Furthermore, IC50's < 500 µg/ml were determined against all cell lines tested against that extract. The methanolic leaf extract was also a potent inhibitor of cell proliferation (Jeg-3 IC50 = 147 µg/ml; MC3T3-E1 IC50 = 40 µg/ml). The fruit extracts were also good inhibitors of carcinoma cell proliferation. Cell imaging studies detected morphological features consistent with apoptosis in Caco2 cells exposed to the ethyl acetate, methanolic, and aqueous extracts. Caspase 3 activity was significantly elevated in Caco2 cells exposed to these extracts, indicating that apoptosis was induced. The leaf ethyl acetate extract contained a high diversity and relative abundance of tannins and flavonoids. All T. ferdinandiana fruit and leaf extracts displayed either no toxic or low toxicity in the Artemia franciscana bioassay and in a HDF viability assay.
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    Journal Title
    Nutrition and Cancer
    Volume
    70
    Issue
    4
    DOI
    https://doi.org/10.1080/01635581.2018.1460680
    Copyright Statement
    © 2018 Taylor & Francis (Routledge). This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 11 Apr 2018, available online: https://www.tandfonline.com/doi/10.1080/01635581.2018.1460680
    Subject
    Nutrition and dietetics
    Oncology and carcinogenesis
    Oncology and carcinogenesis not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/380857
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    • Journal articles

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