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dc.contributor.authorRobson, Roy
dc.contributor.authorKundur, Avinash R
dc.contributor.authorSingh, Indu
dc.date.accessioned2019-06-19T13:07:32Z
dc.date.available2019-06-19T13:07:32Z
dc.date.issued2018
dc.identifier.issn1871-4021
dc.identifier.doi10.1016/j.dsx.2017.12.029
dc.identifier.urihttp://hdl.handle.net/10072/380881
dc.description.abstractAims: Type-2 Diabetes Mellitus (T2DM) is one of the most prevalent and progressive metabolic conditions affecting approximately 8.5% of the global population. Individuals with T2DM have a significantly increased risk of developing chronic conditions such as cardiovascular disease (CVD) and its associated complications, therefore, it is of great importance to establish strategies for combatting T2DM and its associated chronic conditions. Current literature has identified several biomarkers that are known to play a key role in the pathogenesis of CVD. Many of these biomarkers affecting CVD are influenced by an increase in oxidative stress as seen in T2DM. The purpose of this review is to analyse and correlate the oxidative stress-related biomarkers that have been identified in the literature to provide an updated summary of their significance in CVD risk factors. Data synthesis: This review has analysed current research on T2DM, CVD, and oxidative stress. Four key cardiovascular risk factors: thrombosis, inflammation, vascular homeostasis and cellular proliferation were searched to identify potential biomarkers for this review. These biomarkers stem from seven major cellular pathways; NF-kB, Keap1-Nrf2, protein kinase-C, macrophage activation, arachidonic acid mobilisation, endothelial dysfunction and advanced glycation end products. Conclusions: The pathways and biomarkers were analysed to show their role as contributing factors to CVD development and a summary is made regarding the assessment of cardiovascular risk in T2DM individuals.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom455
dc.relation.ispartofpageto462
dc.relation.ispartofjournalDiabetes & Metabolic Syndrome: Clinical Research & Review
dc.relation.ispartofvolume12
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.titleOxidative stress biomarkers in type 2 diabetes mellitus for assessment of cardiovascular disease risk
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.facultyAn Unassigned Group, An Unassigned Department
gro.rights.copyright© 2018 Elsevier on behalf of Diabetes India. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorSingh, Indu
gro.griffith.authorRobson, Roy
gro.griffith.authorKundur, Avinash R.


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