Show simple item record

dc.contributor.authorGopalan, V
dc.contributor.authorLam, AK
dc.contributor.editorAlfred K. Lam
dc.date.accessioned2019-05-29T13:03:04Z
dc.date.available2019-05-29T13:03:04Z
dc.date.issued2018
dc.identifier.isbn9781493977338
dc.identifier.doi10.1007/978-1-4939-7734-5_16
dc.identifier.urihttp://hdl.handle.net/10072/380907
dc.description.abstractWhile circulating tumor cells (CTCs) within peripheral blood of cancer patients are no new phenomenon in many carcinomas, there is a lack of information on the biological and clinical implications of CTCs in esophageal adenocarcinomas. Limited evidence suggests that the CTCs are frequently detected in esophageal adenocarcinomas when compared to esophageal squamous cell carcinoma suggesting the potential difference in the pathogenesis between these two carcinomas. In addition, the varied CTC levels between adenocarcinoma and squamous cell carcinomas of the esophagus could be attributed to the varied expression pattern of epithelial markers such as epithelial cell adhesion molecule (EpCAM) and cytokeratin (CK). In esophageal adenocarcinomas, CTC levels correlated with pathological T stages, lymph node metastasis, and patient survival. Thus, detection of CTCs potentially acts as a noninvasive and real-time biomarker for predicting patient prognosis in esophageal adenocarcinomas. Although the CTC detection is currently performed using various methods, the only Food and Drug Administration (FDA) of USA approved CTC detection method in clinics is the CELLSEARCH® system. This chapter will discuss various biological characteristics of CTC and its potential implications in esophageal adenocarcinomas. In addition, a quick overview of CTC detection methodology is outlined.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science+Business Media, LLC
dc.publisher.placeUnited States
dc.relation.ispartofbooktitleEsophageal Adenocarcinoma: Methods and Protocols
dc.relation.ispartofchapter16
dc.relation.ispartofchapternumbers24
dc.relation.ispartofpagefrom177
dc.relation.ispartofpageto186
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3404
dc.titleCirculatory Tumor Cells in Esophageal Adenocarcinoma
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.facultyGriffith Health, School of Medicine
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.
gro.griffith.authorGopalan, Vinod


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Book chapters
    Contains book chapters authored by Griffith authors.

Show simple item record