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  • Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies

    Author(s)
    Atack, John M
    Tan, Aimee
    Bakaletz, Lauren O
    Jennings, Michael P
    Seib, Kate L
    Griffith University Author(s)
    Jennings, Michael P.
    Seib, Kate
    Atack, John M.
    Year published
    2018
    Metadata
    Show full item record
    Abstract
    A wide variety of bacterial pathogens express phase-variable DNA methyltransferases that control expression of multiple genes via epigenetic mechanisms. These randomly switching regulons – phasevarions – regulate genes involved in pathogenesis, host adaptation, and antibiotic resistance. Individual phase-variable genes can be identified in silico as they contain easily recognized features such as simple sequence repeats (SSRs) or inverted repeats (IRs) that mediate the random switching of expression. Conversely, phasevarion-controlled genes do not contain any easily identifiable features. The study of DNA methyltransferase ...
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    A wide variety of bacterial pathogens express phase-variable DNA methyltransferases that control expression of multiple genes via epigenetic mechanisms. These randomly switching regulons – phasevarions – regulate genes involved in pathogenesis, host adaptation, and antibiotic resistance. Individual phase-variable genes can be identified in silico as they contain easily recognized features such as simple sequence repeats (SSRs) or inverted repeats (IRs) that mediate the random switching of expression. Conversely, phasevarion-controlled genes do not contain any easily identifiable features. The study of DNA methyltransferase specificity using Single-Molecule, Real-Time (SMRT) sequencing and methylome analysis has rapidly advanced the analysis of phasevarions by allowing methylomics to be combined with whole-transcriptome/proteome analysis to comprehensively characterize these systems in a number of important bacterial pathogens.
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    Journal Title
    Trends in Microbiology
    Volume
    26
    Issue
    8
    DOI
    https://doi.org/10.1016/j.tim.2018.01.008
    Funder(s)
    NHMRC
    Grant identifier(s)
    APP1099279
    APP1045235
    Subject
    Microbiology
    Microbiology not elsewhere classified
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/380946
    Collection
    • Journal articles

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