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dc.contributor.authorWilliams, Julian M
dc.contributor.authorKeijzers, Gerben
dc.contributor.authorMacdonald, Stephen PJ
dc.contributor.authorShetty, Amith
dc.contributor.authorFraser, John F
dc.date.accessioned2019-05-29T13:08:09Z
dc.date.available2019-05-29T13:08:09Z
dc.date.issued2018
dc.identifier.issn1742-6731
dc.identifier.doi10.1111/1742-6723.12951
dc.identifier.urihttp://hdl.handle.net/10072/381054
dc.description.abstractAlthough comprehensive guidelines for treatment of sepsis exist, current research continues to refine and revise several aspects of management. Imperatives for rapid administration of broad‐spectrum antibiotics for all patients with sepsis may not be supported by contemporary data. Many patients may be better served by a more judicious approach allowing consideration of investigation results and evidence‐based guidelines. Conventional fluid therapy has been challenged with early evidence supporting balanced, restricted fluid and early vasopressor use. Albumin, vasopressin and hydrocortisone have each been shown to support blood pressure and reduce catecholamine requirements but without effect on mortality, and as such should be considered for ED patients with septic shock on a case‐by‐case basis. Measurement of quality care in sepsis should incorporate quality of blood cultures and guideline‐appropriateness of antibiotics, as well as timeliness of therapy. Local audit is an essential and effective means to improve practice. Multicentre consolidation of data through agreed minimum sepsis data sets would provide baseline quality data, required for the design and evaluation of interventions.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeAustralia
dc.relation.ispartofpagefrom144
dc.relation.ispartofpageto151
dc.relation.ispartofissue2
dc.relation.ispartofjournalEmergency Medicine Australasia
dc.relation.ispartofvolume30
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.titleReview article: Sepsis in the emergency department - Part 3: Treatment
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorKeijzers, Gerben
gro.griffith.authorFraser, John F.


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