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dc.contributor.authorShetty, Amithen_US
dc.contributor.authorMacDonald, Stephenen_US
dc.contributor.authorKeijzers, Gerbenen_US
dc.contributor.authorWilliams, Julianen_US
dc.contributor.authorTang, Benjaminen_US
dc.contributor.authorde Groot, Basen_US
dc.contributor.authorThompson, Kellyen_US
dc.contributor.authorFraser, Johnen_US
dc.contributor.authorFinfer, Simonen_US
dc.contributor.authorBellomo, Rinaldoen_US
dc.contributor.authorIredell, Jonathanen_US
dc.description.abstractSepsis is characterised by organ dysfunction resulting from infection, with no reliable single objective test and current diagnosis based on clinical features and results of investigations. In the ED, investigations may be conducted to diagnose infection as the cause of the presenting illness, identify the source, distinguish sepsis from uncomplicated infection (i.e. without organ dysfunction) and/ or risk stratification. Appropriate sample collection for microbiological testing remains key for subsequent confirmation of diagnosis and rationalisation of antimicrobials. Routine laboratory investigations such as creatinine, bilirubin, platelet count and lactate are now critical elements in the diagnosis of sepsis and septic shock. With no biomarker sufficiently validated to rule out bacterial infection in the ED, there remains substantial interest in biomarkers representing various pathogenic pathways. New technologies for screening multiple genes and proteins are identifying unique network ‘signatures’ of clinical interest. Other future directions include rapid detection of bacterial DNA in blood, genes for antibiotic resistance and EMR‐based computational biomarkers that collate multiple information sources. Reliable, cost‐effective tests, validated in the ED to promptly and accurately identify sepsis, and to guide initial antibiotic choices, are important goals of current research efforts.en_US
dc.publisherWiley-Blackwell Publishingen_US
dc.relation.ispartofjournalEmergency Medicine Australasiaen_US
dc.subject.fieldofresearchClinical Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchPublic Health and Health Servicesen_US
dc.titleReview article: Sepsis in the emergency department - Part 2: Investigations and monitoringen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text

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