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  • Neurodegeneration in ataxia-telangiectasia: Multiple roles of ATM kinase in cellular homeostasis

    Author(s)
    Choy, Kay Rui
    Watters, Dianne J
    Griffith University Author(s)
    Watters, Dianne J.
    Choy, Kay Rui
    Year published
    2018
    Metadata
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    Abstract
    Ataxia‐telangiectasia (A‐T) is characterized by neuronal degeneration, cancer, diabetes, immune deficiency, and increased sensitivity to ionizing radiation. A‐T is attributed to the deficiency of the protein kinase coded by the ATM (ataxia‐telangiectasia mutated) gene. ATM is a sensor of DNA double‐strand breaks (DSBs) and signals to cell cycle checkpoints and the DNA repair machinery. ATM phosphorylates numerous substrates and activates many cell‐signaling pathways. There has been considerable debate about whether a defective DNA damage response is causative of the neurological aspects of the disease. In proliferating cells, ...
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    Ataxia‐telangiectasia (A‐T) is characterized by neuronal degeneration, cancer, diabetes, immune deficiency, and increased sensitivity to ionizing radiation. A‐T is attributed to the deficiency of the protein kinase coded by the ATM (ataxia‐telangiectasia mutated) gene. ATM is a sensor of DNA double‐strand breaks (DSBs) and signals to cell cycle checkpoints and the DNA repair machinery. ATM phosphorylates numerous substrates and activates many cell‐signaling pathways. There has been considerable debate about whether a defective DNA damage response is causative of the neurological aspects of the disease. In proliferating cells, ATM is localized mainly in the nucleus; however, in postmitotic cells such as neurons, ATM is mostly cytoplasmic. Recent studies reveal an increasing number of roles for ATM in the cytoplasm, including activation by oxidative stress. ATM associates with organelles including mitochondria and peroxisomes, both sources of reactive oxygen species (ROS), which have been implicated in neurodegenerative diseases and aging. ATM is also associated with synaptic vesicles and has a role in regulating cellular homeostasis and autophagy. The cytoplasmic roles of ATM provide a new perspective on the neurodegenerative process in A‐T. This review will examine the expanding roles of ATM in cellular homeostasis and relate these functions to the complex A‐T phenotype.
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    Journal Title
    Developmental Dynamics
    Volume
    247
    Issue
    1
    DOI
    https://doi.org/10.1002/dvdy.24522
    Subject
    Biological sciences
    Other biological sciences not elsewhere classified
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/381180
    Collection
    • Journal articles

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