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  • Human disease glycomics: technology advances enabling protein glycosylation analysis - part 2

    Author(s)
    Everest-Dass, Arun V
    Moh, Edward SX
    Ashwood, Christopher
    Shathili, Abdulrahman MM
    Packer, Nicolle H
    Griffith University Author(s)
    Everest-Dass, Arun
    Packer, Nicki
    Year published
    2018
    Metadata
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    Abstract
    Introduction: The changes in glycan structures have been attributed to disease states for several decades. The surface glycosylation pattern is a signature of physiological state of a cell. In this review we provide a link between observed substructural glycan changes and a range of diseases. Areas covered: We highlight biologically relevant glycan substructure expression in cancer, inflammation, neuronal diseases and diabetes. Furthermore, the alterations in antibody glycosylation in a disease context are described. Expert commentary: Advances in technologies, as described in Part 1 of this review have now enabled the ...
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    Introduction: The changes in glycan structures have been attributed to disease states for several decades. The surface glycosylation pattern is a signature of physiological state of a cell. In this review we provide a link between observed substructural glycan changes and a range of diseases. Areas covered: We highlight biologically relevant glycan substructure expression in cancer, inflammation, neuronal diseases and diabetes. Furthermore, the alterations in antibody glycosylation in a disease context are described. Expert commentary: Advances in technologies, as described in Part 1 of this review have now enabled the characterization of specific glycan structural markers of a range of disease states. The requirement of including glycomics in cross-disciplinary omics studies, such as genomics, proteomics, epigenomics, transcriptomics and metabolomics towards a systems glycobiology approach to understanding disease mechanisms and management are highlighted.
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    Journal Title
    Expert Review of Proteomics
    Volume
    15
    Issue
    4
    DOI
    https://doi.org/10.1080/14789450.2018.1448710
    Subject
    Biochemistry and cell biology
    Biochemistry and cell biology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/381234
    Collection
    • Journal articles

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