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dc.contributor.authorEverest-Dass, Arun V
dc.contributor.authorMoh, Edward SX
dc.contributor.authorAshwood, Christopher
dc.contributor.authorShathili, Abdulrahman MM
dc.contributor.authorPacker, Nicolle H
dc.date.accessioned2019-07-04T12:39:36Z
dc.date.available2019-07-04T12:39:36Z
dc.date.issued2018
dc.identifier.issn1478-9450
dc.identifier.doi10.1080/14789450.2018.1448710
dc.identifier.urihttp://hdl.handle.net/10072/381234
dc.description.abstractIntroduction: The changes in glycan structures have been attributed to disease states for several decades. The surface glycosylation pattern is a signature of physiological state of a cell. In this review we provide a link between observed substructural glycan changes and a range of diseases. Areas covered: We highlight biologically relevant glycan substructure expression in cancer, inflammation, neuronal diseases and diabetes. Furthermore, the alterations in antibody glycosylation in a disease context are described. Expert commentary: Advances in technologies, as described in Part 1 of this review have now enabled the characterization of specific glycan structural markers of a range of disease states. The requirement of including glycomics in cross-disciplinary omics studies, such as genomics, proteomics, epigenomics, transcriptomics and metabolomics towards a systems glycobiology approach to understanding disease mechanisms and management are highlighted.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherTaylor & Francis
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom341
dc.relation.ispartofpageto352
dc.relation.ispartofissue4
dc.relation.ispartofjournalExpert Review of Proteomics
dc.relation.ispartofvolume15
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchcode060199
dc.subject.fieldofresearchcode0601
dc.titleHuman disease glycomics: technology advances enabling protein glycosylation analysis - part 2
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.hasfulltextNo Full Text
gro.griffith.authorEverest-Dass, Arun
gro.griffith.authorPacker, Nicki


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