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  • Present Status and Future Challenges of New Therapeutic Targets in Preclinical Models of Stroke in Aged Animals with/without Comorbidities

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    Popa-WagnerPUB6949.pdf (626.6Kb)
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    Author(s)
    Popa-Wagner, Aurel
    Glavan, Daniela-Gabriela
    Olaru, Andrei
    Olaru, Denissa-Greta
    Margaritescu, Otilia
    Tica, Oana
    Surugiu, Roxana
    Sandu, Raluca Elena
    Griffith University Author(s)
    Popa-Wagner, Aurel
    Year published
    2018
    Metadata
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    Abstract
    The aging process, comorbidities, and age-associated diseases are closely dependent on each other. Cerebral ischemia impacts a wide range of systems in an age-dependent manner. However, the aging process has many facets which are influenced by the genetic background and epigenetic or environmental factors, which can explain why some people age differently than others. Therefore, there is an urgent need to identify age-related changes in body functions or structures that increase the risk for stroke and which are associated with a poor outcome. Multimodal imaging, electrophysiology, cell biology, proteomics, and transcriptomics, ...
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    The aging process, comorbidities, and age-associated diseases are closely dependent on each other. Cerebral ischemia impacts a wide range of systems in an age-dependent manner. However, the aging process has many facets which are influenced by the genetic background and epigenetic or environmental factors, which can explain why some people age differently than others. Therefore, there is an urgent need to identify age-related changes in body functions or structures that increase the risk for stroke and which are associated with a poor outcome. Multimodal imaging, electrophysiology, cell biology, proteomics, and transcriptomics, offer a useful approach to link structural and functional changes in the aging brain, with or without comorbidities, to post-stroke rehabilitation. This can help us to improve our knowledge about senescence firstly, and in this context, aids in elucidating the pathophysiology of age-related diseases that allows us to develop therapeutic strategies or prevent diseases. These processes, including potential therapeutical interventions, need to be studied first in relevant preclinical models using aged animals, with and without comorbidities. Therefore, preclinical research on ischemic stroke should consider age as the most important risk factor for cerebral ischemia. Furthermore, the identification of effective therapeutic strategies, corroborated with successful translational studies, will have a dramatic impact on the lives of millions of people with cerebrovascular diseases.
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    Journal Title
    International Journal of Molecular Sciences
    Volume
    19
    Issue
    2
    DOI
    https://doi.org/10.3390/ijms19020356
    Copyright Statement
    © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
    Subject
    Other chemical sciences
    Genetics
    Other biological sciences
    Other biological sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/381244
    Collection
    • Journal articles

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