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dc.contributor.authorFahmi, Mochamad Zakki
dc.contributor.authorHaris, Abdul
dc.contributor.authorPermana, Ahmadi Jaya
dc.contributor.authorWibowo, Denika Liyan Nor
dc.contributor.authorPurwanto, Bambang
dc.contributor.authorNikmah, Yatim Lailun
dc.contributor.authorIdris, Adi
dc.description.abstractIn this study, carbon dots synthesized from bamboo leaf cellulose were used simultaneously as a staining agent and for doxorubicin delivery to target cancer cells. Owing to their nontoxic properties, the production of carbon dots from bamboo leaves is a green approach involving optimized application of bamboo tree waste. For multifunctional applications, the carbon dots were modified with 4-carboxybenzylboronic acid and doxorubicin to improve target specificity and drug delivery to HeLa tumor cells. The resulting modified carbon dots were characterized using different analytical techniques, which showed that they were biocompatible, nontoxic, and highly stable over a wide range of pH values and at high ionic strengths. Furthermore, in vitro confocal microscopy studies demonstrated their blue fluorescence and cellular pathway for entering HeLa cells via folate receptor-mediated endocytosis. Cell viability data and flow cytometry results also confirmed the selective uptake of the carbon dots by HeLa cells, which significantly enhanced cell cytotoxicity.
dc.publisherRoyal Society of Chemistry
dc.publisher.placeUnited Kingdom
dc.relation.ispartofjournalRSC Advances
dc.subject.fieldofresearchNanochemistry and Supramolecular Chemistry
dc.subject.fieldofresearchChemical Sciences
dc.titleBamboo leaf-based carbon dots for efficient tumor imaging and therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorIdris, Adi

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