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dc.contributor.authorFahmi, Mochamaden_US
dc.contributor.authorHaris, Abdulen_US
dc.contributor.authorPermana, Ahmadien_US
dc.contributor.authorWibowo, Denikaen_US
dc.contributor.authorPurwanto, Bambangen_US
dc.contributor.authorNikmah, Yatimen_US
dc.contributor.authorIdris, Adien_US
dc.date.accessioned2019-05-29T12:39:13Z
dc.date.available2019-05-29T12:39:13Z
dc.date.issued2018en_US
dc.identifier.issn2046-2069en_US
dc.identifier.doi10.1039/c8ra07944gen_US
dc.identifier.urihttp://hdl.handle.net/10072/381274
dc.description.abstractIn this study, carbon dots synthesized from bamboo leaf cellulose were used simultaneously as a staining agent and for doxorubicin delivery to target cancer cells. Owing to their nontoxic properties, the production of carbon dots from bamboo leaves is a green approach involving optimized application of bamboo tree waste. For multifunctional applications, the carbon dots were modified with 4-carboxybenzylboronic acid and doxorubicin to improve target specificity and drug delivery to HeLa tumor cells. The resulting modified carbon dots were characterized using different analytical techniques, which showed that they were biocompatible, nontoxic, and highly stable over a wide range of pH values and at high ionic strengths. Furthermore, in vitro confocal microscopy studies demonstrated their blue fluorescence and cellular pathway for entering HeLa cells via folate receptor-mediated endocytosis. Cell viability data and flow cytometry results also confirmed the selective uptake of the carbon dots by HeLa cells, which significantly enhanced cell cytotoxicity.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofpagefrom38376en_US
dc.relation.ispartofpageto38383en_US
dc.relation.ispartofjournalRSC Advancesen_US
dc.relation.ispartofvolume8en_US
dc.subject.fieldofresearchNanochemistry and Supramolecular Chemistryen_US
dc.subject.fieldofresearchcode030302en_US
dc.titleBamboo leaf-based carbon dots for efficient tumor imaging and therapyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text


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