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dc.contributor.authorSmith, Daviden_US
dc.contributor.authorCalopedos, Rossen_US
dc.contributor.authorBang, Alberten_US
dc.contributor.authorYu, Xueen_US
dc.contributor.authorEgger, Samen_US
dc.contributor.authorChambers, Suzanneen_US
dc.contributor.authorO'Connell, Dianneen_US
dc.date.accessioned2019-05-29T12:39:27Z
dc.date.available2019-05-29T12:39:27Z
dc.date.issued2018en_US
dc.identifier.issn1932-6203en_US
dc.identifier.doi10.1371/journal.pone.0198679en_US
dc.identifier.urihttp://hdl.handle.net/10072/381307
dc.description.abstractBackground: An elevated risk of suicide after a diagnosis of prostate cancer has been reported previously in the USA and Sweden. We aimed to identify whether prostate cancer survivors resident in New South Wales Australia are at higher risk of suicide and if so, who is most at risk. Methods: Data were obtained from the New South Wales (NSW) Cancer Registry for all men diagnosed with prostate cancer in NSW during 1997 to 2007. These were linked by the Centre for Health Record Linkage (CHeReL) to Australian Bureau of Statistics Mortality Data to the end of 2007 to determine vital status and cause of death. We compared the number of suicides observed for prostate cancer survivors with the expected number of suicides based on age- and calendar year- specific rates for the NSW male population using standardised mortality ratios (SMRs). Suicide rate ratios (RR) by disease and patients’ characteristics were estimated using multivariable negative binomial regression to determine the most at risk groups. Results: During the study period 51,924 NSW men were diagnosed with prostate cancer. Forty nine of these men were subsequently recorded as committing suicide up to 10 years after diagnosis with an SMR of 1.70 (95% CI:1.26–2.25). Twenty six (53%) of these suicides occurred within 12 months after diagnosis. Risk diminished over time since diagnosis (RR in 1–2 years after diagnosis = 0.29, 95% CI: 0.12–0.71, 2–4 years RR = 0.30, 95% CI: 0.14–0.16 and 4+ years RR = 0.26, 95% CI: 0.11–0.60 compared with <1 year since diagnosis). Men with non-localised disease had a higher risk of suicide compared to men with localised disease (RR = 2.68, 95% CI: 1.15–6.23). Men living outside major cities had lower risk of suicide compared to those resident in major cities (rate ratio = 0.42, 95% CI: 0.20–0.87). Single, divorced, widowed or separated men were more likely to commit suicide than married men (RR = 4.18, 95% CI: 2.36–7.42). Conclusion: Risk of suicide is higher for NSW men diagnosed with prostate cancer than the general age matched male population. Vulnerable or lonely men and those with pre-existing depression or suicidal ideation who are diagnosed with prostate cancer should be offered additional psychological support.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherPublic Library of Sciencesen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto12en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalPLoS Oneen_US
dc.relation.ispartofvolume13en_US
dc.subject.fieldofresearchPsychology not elsewhere classifieden_US
dc.subject.fieldofresearchMultidisciplinaryen_US
dc.subject.fieldofresearchcode170199en_US
dc.subject.fieldofresearchcodeMDen_US
dc.titleIncreased risk of suicide in New South Wales men with prostate cancer: Analysis of linked population-wide dataen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.description.versionPublisheden_US
gro.facultyGriffith Health, Menzies Health Instituteen_US
gro.rights.copyright© 2018 Smith et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
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