dc.contributor.author | Boersch, M | |
dc.contributor.author | Rudrawar, S | |
dc.contributor.author | Grant, G | |
dc.contributor.author | Zunk, M | |
dc.date.accessioned | 2019-05-29T13:09:03Z | |
dc.date.available | 2019-05-29T13:09:03Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2046-2069 | |
dc.identifier.doi | 10.1039/c7ra12950e | |
dc.identifier.uri | http://hdl.handle.net/10072/381359 | |
dc.description.abstract | Menaquinone is essential in electron transport and ATP generation in all Gram-positive, and anaerobically respiring Gram-negative bacteria. By inhibiting menaquinone production in target organisms, bactericidal action can be achieved irrespective of the organisms' growth phase. This pathway is absent in human cells, as menaquinone is obtained only through the diet. This paper provides a succinct review of major advancements, where present, at all enzymatic steps of the biosynthetic pathway of menaquinone. Structure–activity relationships are evaluated, as well as results translating these relationships to growth inhibition studies. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Royal Society of Chemistry | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofpagefrom | 5099 | |
dc.relation.ispartofpageto | 5105 | |
dc.relation.ispartofjournal | RSC Advances | |
dc.relation.ispartofvolume | 8 | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Other chemical sciences not elsewhere classified | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 349999 | |
dc.title | Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by/3.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.faculty | An Unassigned Group, An Unassigned Department | |
gro.rights.copyright | © 2018 The Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Zunk, Matthew S. | |
gro.griffith.author | Grant, Gary D. | |
gro.griffith.author | Rudrawar, Santosh | |