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dc.contributor.authorBoersch, M
dc.contributor.authorRudrawar, S
dc.contributor.authorGrant, G
dc.contributor.authorZunk, M
dc.date.accessioned2019-05-29T13:09:03Z
dc.date.available2019-05-29T13:09:03Z
dc.date.issued2018
dc.identifier.issn2046-2069
dc.identifier.doi10.1039/c7ra12950e
dc.identifier.urihttp://hdl.handle.net/10072/381359
dc.description.abstractMenaquinone is essential in electron transport and ATP generation in all Gram-positive, and anaerobically respiring Gram-negative bacteria. By inhibiting menaquinone production in target organisms, bactericidal action can be achieved irrespective of the organisms' growth phase. This pathway is absent in human cells, as menaquinone is obtained only through the diet. This paper provides a succinct review of major advancements, where present, at all enzymatic steps of the biosynthetic pathway of menaquinone. Structure–activity relationships are evaluated, as well as results translating these relationships to growth inhibition studies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom5099
dc.relation.ispartofpageto5105
dc.relation.ispartofjournalRSC Advances
dc.relation.ispartofvolume8
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchOther chemical sciences not elsewhere classified
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode349999
dc.titleMenaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/3.0/
dc.description.versionVersion of Record (VoR)
gro.facultyAn Unassigned Group, An Unassigned Department
gro.rights.copyright© 2018 The Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorZunk, Matthew S.
gro.griffith.authorGrant, Gary D.
gro.griffith.authorRudrawar, Santosh


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