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dc.contributor.authorShim, Vickie B
dc.contributor.authorHansen, Wencke
dc.contributor.authorNewsham-West, Richard
dc.contributor.authorNuri, Leila
dc.contributor.authorObst, Steven
dc.contributor.authorPizzolato, Claudio
dc.contributor.authorLloyd, David G
dc.contributor.authorBarrett, Rod S
dc.date.accessioned2019-06-26T06:00:57Z
dc.date.available2019-06-26T06:00:57Z
dc.date.issued2019
dc.identifier.issn0021-9290
dc.identifier.doi10.1016/j.jbiomech.2018.10.027
dc.identifier.urihttp://hdl.handle.net/10072/381435
dc.description.abstractAchilles tendon material properties and geometry are altered in Achilles tendinopathy. The purpose of this study was to determine the relative contributions of altered material properties and geometry to free Achilles tendon stress distribution during a sub-maximal contraction in tendinopathic relative to healthy tendons. Tendinopathic (n = 8) and healthy tendons (n = 8) were imaged at rest and during a sub-maximal voluntary isometric contraction using three-dimensional freehand ultrasound. Images were manually segmented and used to create subject-specific finite element models. The resting cross-sectional area of the free tendon was on average 31% greater for the tendinopathic compared to healthy tendons. Material properties for each tendon were determined using a numerical parameter optimisation approach that minimised the difference in experimentally measured longitudinal strain and the strain predicted by the finite element model under submaximal loading conditions for each tendon. The mean Young’s modulus for tendinopathic tendons was 53% lower than the corresponding control value. Finite element analyses revealed that tendinopathic tendons experience 24% less stress under the same submaximal external loading conditions compared to healthy tendons. The lower tendon stress in tendinopathy was due to a greater influence of tendon cross-sectional area, which alone reduced tendon stress by 30%, compared to a lower Young’s modulus, which alone increased tendon stress by 8%. These findings suggest that the greater tendon cross-sectional area observed in tendinopathy compensates for the substantially lower Young’s modulus, thereby protecting pathological tendon against excessive stress.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto7
dc.relation.ispartofjournalJournal of Biomechanics
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchMechanical engineering
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchBiomechanics
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode4017
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode420701
dc.titleInfluence of altered geometry and material properties on tissue stress distribution under load in tendinopathic Achilles tendons - A subject-specific finite element analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorBarrett, Rod
gro.griffith.authorNewsham-West, Richard J.
gro.griffith.authorLloyd, David
gro.griffith.authorHansen, Wenx
gro.griffith.authorPizzolato, Claudio
gro.griffith.authorNuri, Leila
gro.griffith.authorObst, Steven J.


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