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  • Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive

    Author(s)
    Escher, Beate I
    Ait-Aissa, Selim
    Behnisch, Peter A
    Brack, Werner
    Brion, Francois
    Brouwer, Abraham
    Buchinger, Sebastian
    Crawford, Sarah E
    Du Pasquier, David
    Hamers, Timo
    Hettwer, Karina
    Hilscherova, Klara
    Hollert, Henner
    Kase, Robert
    Kienle, Cornelia
    Tindall, Andrew J
    Tuerk, Jochen
    van der Oost, Ron
    Vermeirssen, Etienne
    Neale, Peta A
    Griffith University Author(s)
    Neale, Peta A.
    Year published
    2018
    Metadata
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    Abstract
    Effect-based methods including cell-based bioassays, reporter gene assays and whole-organism assays have been applied for decades in water quality monitoring and testing of enriched solid-phase extracts. There is no common EU-wide agreement on what level of bioassay response in water extracts is acceptable. At present, bioassay results are only benchmarked against each other but not against a consented measure of chemical water quality. The EU environmental quality standards (EQS) differentiate between acceptable and unacceptable surface water concentrations for individual chemicals but cannot capture the thousands of chemicals ...
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    Effect-based methods including cell-based bioassays, reporter gene assays and whole-organism assays have been applied for decades in water quality monitoring and testing of enriched solid-phase extracts. There is no common EU-wide agreement on what level of bioassay response in water extracts is acceptable. At present, bioassay results are only benchmarked against each other but not against a consented measure of chemical water quality. The EU environmental quality standards (EQS) differentiate between acceptable and unacceptable surface water concentrations for individual chemicals but cannot capture the thousands of chemicals in water and their biological action as mixtures. We developed a method that reads across from existing EQS and includes additional mixture considerations with the goal that the derived effect-based trigger values (EBT) indicate acceptable risk for complex mixtures as they occur in surface water. Advantages and limitations of various approaches to read across from EQS are discussed and distilled to an algorithm that translates EQS into their corresponding bioanalytical equivalent concentrations (BEQ). The proposed EBT derivation method was applied to 48 in vitro bioassays with 32 of them having sufficient information to yield preliminary EBTs. To assess the practicability and robustness of the proposed approach, we compared the tentative EBTs with observed environmental effects. The proposed method only gives guidance on how to derive EBTs but does not propose final EBTs for implementation. The EBTs for some bioassays such as those for estrogenicity are already mature and could be implemented into regulation in the near future, while for others it will still take a few iterations until we can be confident of the power of the proposed EBTs to differentiate good from poor water quality with respect to chemical contamination.
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    Journal Title
    Science of the Total Environment
    Volume
    628-629
    DOI
    https://doi.org/10.1016/j.scitotenv.2018.01.340
    Funder(s)
    NHMRC
    Grant identifier(s)
    APP1074775
    Subject
    Environmental marine biotechnology
    Publication URI
    http://hdl.handle.net/10072/381453
    Collection
    • Journal articles

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