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dc.contributor.authorI. Stanisic, Danielleen_US
dc.contributor.authorS. Richards, Jacken_US
dc.contributor.authorJ. McCallum, Fionaen_US
dc.contributor.authorMichon, Pascalen_US
dc.contributor.authorL. King, Christopheren_US
dc.contributor.authorSchoepflin, Sonjaen_US
dc.contributor.authorR. Gilson, Paulen_US
dc.contributor.authorJ. Murphy, Vincenten_US
dc.contributor.authorF. Anders, Robinen_US
dc.contributor.authorMueller, Ivoen_US
dc.contributor.authorG. Beeson, Jamesen_US
dc.date.accessioned2017-04-24T13:39:00Z
dc.date.available2017-04-24T13:39:00Z
dc.date.issued2009en_US
dc.date.modified2011-04-14T07:00:24Z
dc.identifier.issn00199567en_US
dc.identifier.doi10.1128/IAI.01129-08en_AU
dc.identifier.urihttp://hdl.handle.net/10072/38165
dc.description.abstractSubstantial evidence indicates that antibodies to Plasmodium falciparum merozoite antigens play a role in protection from malaria, although the precise targets and mechanisms mediating immunity remain unclear. Different malaria antigens induce distinct immunoglobulin G (IgG) subclass responses, but the importance of different responses in protective immunity from malaria is not known and the factors determining subclass responses in vivo are poorly understood. We examined IgG and IgG subclass responses to the merozoite antigens MSP1-19 (the 19-kDa C-terminal region of merozoite surface protein 1), MSP2 (merozoite surface protein 2), and AMA-1 (apical membrane antigen 1), including different polymorphic variants of these antigens, in a longitudinal cohort of children in Papua New Guinea. IgG1 and IgG3 were the predominant subclasses of antibodies to each antigen, and all antibody responses increased in association with age and exposure without evidence of increasing polarization toward one subclass. The profiles of IgG subclasses differed somewhat for different alleles of MSP2 but not for different variants of AMA-1. Individuals did not appear to have a propensity to make a specific subclass response irrespective of the antigen. Instead, data suggest that subclass responses to each antigen are generated independently among individuals and that antigen properties, rather than host factors, are the major determinants of IgG subclass responses. High levels of AMA-1-specific IgG3 and MSP1-19-specific IgG1 were strongly predictive of a reduced risk of symptomatic malaria and high-density P. falciparum infections. However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican Society for Microbiologyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1165en_US
dc.relation.ispartofpageto1174en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalInfection and Immunityen_US
dc.relation.ispartofvolume77en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchHumoural Immunology and Immunochemistryen_US
dc.subject.fieldofresearchcode110705en_US
dc.titleImmunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illnessen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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