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dc.contributor.authorZhong, Weien_US
dc.contributor.authorSkwarczynski, Mariuszen_US
dc.contributor.authorFujita, Yoshioen_US
dc.contributor.authorSimerska, Pavlaen_US
dc.contributor.authorF. Good, Michaelen_US
dc.contributor.authorToth, Istvanen_US
dc.date.accessioned2017-04-24T08:44:53Z
dc.date.available2017-04-24T08:44:53Z
dc.date.issued2009en_US
dc.date.modified2011-04-14T07:00:49Z
dc.identifier.issn00049425en_US
dc.identifier.doi10.1071/CH09065en_AU
dc.identifier.urihttp://hdl.handle.net/10072/38169
dc.description.abstractDevelopment of a synthetic vaccine against group A streptococcal infection is increasingly paramount due to the induction of autoimmunity by the main virulent factor - M protein. Peptide vaccines, however, are generally poorly immunogenic, necessitating administration with carriers and adjuvants. One of the promising approaches to deliver antigenic peptides is to assemble peptides on a suitable template which directs the attached peptides to form a well defined tertiary structure. For self-adjuvanting human vaccines, the conjugation of immunostimulatory lipids has been demonstrated as a potentially safe method. This study describes the design and optimized synthesis of two lipopeptide conjugated carbohydrate templates and the assembling of peptide antigens. These lipopeptide-carbohydrate assembled multivalent vaccine candidates were obtained in high yield and purity when native chemical ligation was applied. Circular dichroism studies indicated that the template-assembled peptides form four a-helix bundles. The developed technique extends the use of carbohydrate templates and lipopeptide conjugates for producing self-adjuvanting and topology-controlled vaccine candidates.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherCSIRO Publishingen_US
dc.publisher.placeAustraliaen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom993en_US
dc.relation.ispartofpageto999en_US
dc.relation.ispartofissue9en_US
dc.relation.ispartofjournalAustralian Journal of Chemistryen_US
dc.relation.ispartofvolume62en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchInfectious Diseasesen_US
dc.subject.fieldofresearchcode110309en_US
dc.titleDesign and synthesis of lipopeptide-carbohydrate assembled multivalent vaccine candidates using native chemical ligationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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