Compression socks and the effects on coagulation and fibrinolytic activation during marathon running
Author(s)
Zadow, EK
Adams, MJ
Wu, SSX
Kitic, CM
Singh, I
Kundur, A
Bost, N
Johnston, ANB
Crilly, J
Bulmer, AC
Halson, SL
Fell, JW
Griffith University Author(s)
Year published
2018
Metadata
Show full item recordAbstract
Purpose
Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear.
Objectives
To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon.
Methods
Sixty-seven participants [43 males (mean ± SD: age: 46.7 ± 10.3 year) and 24 females (age: 40.0 ± 11.0 year)] were allocated into a compression (SOCK, n = 34) or control (CONTROL, n = 33) group. Venous blood samples were obtained 24 h prior to and immediately ...
View more >Purpose Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear. Objectives To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon. Methods Sixty-seven participants [43 males (mean ± SD: age: 46.7 ± 10.3 year) and 24 females (age: 40.0 ± 11.0 year)] were allocated into a compression (SOCK, n = 34) or control (CONTROL, n = 33) group. Venous blood samples were obtained 24 h prior to and immediately POST-marathon, and were analyzed for thrombin–anti-thrombin complex (TAT), tissue factor (TF), tissue factor pathway inhibitor (TFPI), and D-Dimer. Results Compression significantly attenuated the post-exercise increase in D-Dimer compared to the control group [median (range) SOCK: + 9.02 (− 0.34 to 60.7) ng/mL, CONTROL: + 25.48 (0.95–73.24) ng/mL]. TF increased following the marathon run [median (range), SOCK: + 1.19 (− 7.47 to 9.11) pg/mL, CONTROL: + 3.47 (− 5.01 to 38.56) pg/mL] in all runners. No significant post-exercise changes were observed for TAT and TFPI. Conclusions While activation of coagulation and fibrinolysis was apparent in all runners POST-marathon, wearing compression socks was shown to reduce fibrinolytic activity, as demonstrated by lower D-Dimer concentrations. Compression may reduce exercise-associated haemostatic activation when completing prolonged exercise.
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View more >Purpose Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear. Objectives To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon. Methods Sixty-seven participants [43 males (mean ± SD: age: 46.7 ± 10.3 year) and 24 females (age: 40.0 ± 11.0 year)] were allocated into a compression (SOCK, n = 34) or control (CONTROL, n = 33) group. Venous blood samples were obtained 24 h prior to and immediately POST-marathon, and were analyzed for thrombin–anti-thrombin complex (TAT), tissue factor (TF), tissue factor pathway inhibitor (TFPI), and D-Dimer. Results Compression significantly attenuated the post-exercise increase in D-Dimer compared to the control group [median (range) SOCK: + 9.02 (− 0.34 to 60.7) ng/mL, CONTROL: + 25.48 (0.95–73.24) ng/mL]. TF increased following the marathon run [median (range), SOCK: + 1.19 (− 7.47 to 9.11) pg/mL, CONTROL: + 3.47 (− 5.01 to 38.56) pg/mL] in all runners. No significant post-exercise changes were observed for TAT and TFPI. Conclusions While activation of coagulation and fibrinolysis was apparent in all runners POST-marathon, wearing compression socks was shown to reduce fibrinolytic activity, as demonstrated by lower D-Dimer concentrations. Compression may reduce exercise-associated haemostatic activation when completing prolonged exercise.
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Journal Title
European Journal of Applied Physiology
Volume
118
Issue
10
Subject
Haematology
Sports science and exercise
Tissue factor
Tissue factor pathway inhibitor
Thrombin–anti-thrombin complexes
Compression
D-dimer