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dc.contributor.authorCroaker, Andrew
dc.contributor.authorKing, Graham J
dc.contributor.authorPyne, John H
dc.contributor.authorAnoopkumar-Dukie, Shailendra
dc.contributor.authorLiu, Lei
dc.date.accessioned2019-05-29T13:13:25Z
dc.date.available2019-05-29T13:13:25Z
dc.date.issued2018
dc.identifier.issn0260-437X
dc.identifier.doi10.1002/jat.3619
dc.identifier.urihttp://hdl.handle.net/10072/381814
dc.description.abstractEpidemic dropsy is a potentially life‐threatening condition resulting from the ingestion of argemone oil derived from the seeds of Argemone mexicana Linn. Exposure to argemone oil is usually inadvertent, arising from mustard cooking oil adulteration. Sanguinarine, an alkaloid present in argemone oil, has been postulated as a causative agent with the severity of epidemic dropsy correlating with plasma sanguinarine levels. Cases of epidemic dropsy have also been reported following the topical application of argemone containing massage oil. Black salve, a topical skin cancer therapy also contains sanguinarine, but at significantly higher concentrations than that reported for contaminated massage oil. Although not reported to date, a theoretical risk therefore exists of black salve inducing epidemic dropsy. This literature review explores the presentation and pathophysiology of epidemic dropsy and assesses the risk of it being induced by black salve.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom1274
dc.relation.ispartofpageto1281
dc.relation.ispartofissue10
dc.relation.ispartofjournalJournal of Applied Toxicology
dc.relation.ispartofvolume38
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classified
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode111599
dc.subject.fieldofresearchcode1115
dc.titleAssessing the risk of epidemic dropsy from black salve use
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorAnoopkumar-Dukie, Shailendra


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