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  • Delta Opioid Receptors and Cardioprotection

    Author(s)
    Hoe, Louise See
    Patel, Hemal H
    Peart, Jason N
    Griffith University Author(s)
    Peart, Jason N.
    Year published
    2018
    Metadata
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    Abstract
    The opioid receptor family, with associated endogenous ligands, has numerous roles throughout the body. Moreover, the delta opioid receptor (DORs) has various integrated roles within the physiological systems, including the cardiovascular system. While DORs are important modulators of cardiovascular autonomic balance, they are well-established contributors to cardioprotective mechanisms. Both endogenous and exogenous opioids acting upon DORs have roles in myocardial hibernation and protection against ischaemia-reperfusion (I-R) injury. Downstream signalling mechanisms governing protective responses alternate, depending on ...
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    The opioid receptor family, with associated endogenous ligands, has numerous roles throughout the body. Moreover, the delta opioid receptor (DORs) has various integrated roles within the physiological systems, including the cardiovascular system. While DORs are important modulators of cardiovascular autonomic balance, they are well-established contributors to cardioprotective mechanisms. Both endogenous and exogenous opioids acting upon DORs have roles in myocardial hibernation and protection against ischaemia-reperfusion (I-R) injury. Downstream signalling mechanisms governing protective responses alternate, depending on the timing and duration of DOR activation. The following review describes models and mechanisms of DOR-mediated cardioprotection, the impact of co-morbidities and challenges for clinical translation.
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    Book Title
    Delta Opioid Receptor Pharmacology and Therapeutic Applications
    DOI
    https://doi.org/10.1007/164_2017_6
    Subject
    Other health sciences not elsewhere classified
    Other biomedical and clinical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/381919
    Collection
    • Book chapters

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