Show simple item record

dc.contributor.authorHartley-Tassell, LE
dc.contributor.authorDay, CJ
dc.contributor.authorSemchenko, EA
dc.contributor.authorTram, G
dc.contributor.authorCalderon-Gomez, LI
dc.contributor.authorKlipic, Z
dc.contributor.authorBarry, AM
dc.contributor.authorLam, AK
dc.contributor.authorMcGuckin, MA
dc.contributor.authorKorolik, V
dc.date.accessioned2019-07-04T12:41:58Z
dc.date.available2019-07-04T12:41:58Z
dc.date.issued2018
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/s41598-018-30604-5
dc.identifier.urihttp://hdl.handle.net/10072/382084
dc.description.abstractAn attenuated Campylobacter jejuni aspartate chemoreceptor ccaA mutant caused gross pathological changes despite reduced colonisation ability in animal models. In chickens, the pathological changes included connective tissue and thickening of the mesenteric fat, as well as the disintegration of the villus tips in the large intestine, whereas in mice, hepatomegaly occurred between 48–72 hours post infection and persisted for the six days of the time course. In addition, there was a significant change in the levels of IL-12p70 in mice infected with the C. jejuni ccaA mutant. CcaA isogenic mutant was hyper-invasive in cell culture and microscopic examination revealed that it had a “run” bias in its “run-and-tumble” chemotactic behaviour. The mutant cells also exhibited lower level of binding to fucosylated and higher binding to sialylated glycan structures in glycan array analysis. This study highlights the importance of investigating phenotypic changes in C. jejuni, as we have shown that specific mutants can cause pathological changes in the host, despite reduction in colonisation potential.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited Kingdom
dc.relation.ispartofchapter12594
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto13
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume8
dc.subject.fieldofresearchPathology (excl. oral pathology)
dc.subject.fieldofresearchcode320220
dc.titleA peculiar case of Campylobacter jejuni attenuated aspartate chemosensory mutant, able to cause pathology and inflammation in avian and murine model animals
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.rights.copyright© The Author(s) 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorKorolik, Victoria
gro.griffith.authorDay, Christopher J.
gro.griffith.authorLam, Alfred K.
gro.griffith.authorSemchenko, Evgeny
gro.griffith.authorTram, Greg C.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record