dc.contributor.author | Carter, James R | |
dc.contributor.author | Kiefel, Milton J | |
dc.date.accessioned | 2019-05-29T13:16:12Z | |
dc.date.available | 2019-05-29T13:16:12Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2046-2069 | |
dc.identifier.doi | 10.1039/C8RA07771A | |
dc.identifier.uri | http://hdl.handle.net/10072/382126 | |
dc.description.abstract | Legionaminic acid is a member of the nonulosonic acids, which are a class of sugars considered to be a virulence factor within a wide variety of pathogenic bacteria. We have developed a synthetic pathway towards C-7 analogues of legionaminic acid starting from Neu5Ac, resulting in the complete synthesis of both legionaminic acid, and its C-7 epimer, from a common precurser. Our approach involves the late-stage introduction of the requisite C-7 nitrogen functionality, thus making our strategy amenable to the introduction of a range of different amide groups at C-7 of legionaminic acid. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Royal Society of Chemistry | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofpagefrom | 35768 | |
dc.relation.ispartofpageto | 35775 | |
dc.relation.ispartofjournal | RSC Advances | |
dc.relation.ispartofvolume | 8 | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Other chemical sciences not elsewhere classified | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 349999 | |
dc.title | A new approach to the synthesis of legionaminic acid analogues | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by-nc/3.0/ | |
gro.faculty | Office of the Snr Dep Vice Chancellor, Institute for Glycomics | |
gro.rights.copyright | © The Author(s) 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Kiefel, Milton | |