Show simple item record

dc.contributor.authorCarter, James R
dc.contributor.authorKiefel, Milton J
dc.date.accessioned2019-05-29T13:16:12Z
dc.date.available2019-05-29T13:16:12Z
dc.date.issued2018
dc.identifier.issn2046-2069
dc.identifier.doi10.1039/C8RA07771A
dc.identifier.urihttp://hdl.handle.net/10072/382126
dc.description.abstractLegionaminic acid is a member of the nonulosonic acids, which are a class of sugars considered to be a virulence factor within a wide variety of pathogenic bacteria. We have developed a synthetic pathway towards C-7 analogues of legionaminic acid starting from Neu5Ac, resulting in the complete synthesis of both legionaminic acid, and its C-7 epimer, from a common precurser. Our approach involves the late-stage introduction of the requisite C-7 nitrogen functionality, thus making our strategy amenable to the introduction of a range of different amide groups at C-7 of legionaminic acid.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom35768
dc.relation.ispartofpageto35775
dc.relation.ispartofjournalRSC Advances
dc.relation.ispartofvolume8
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchOther chemical sciences not elsewhere classified
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode349999
dc.titleA new approach to the synthesis of legionaminic acid analogues
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc/3.0/
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.rights.copyright© The Author(s) 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorKiefel, Milton


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record