Show simple item record

dc.contributor.authorBulmer, Andrew C
dc.contributor.authorBakrania, Bhavisha
dc.contributor.authorDu Toit, Eugene F
dc.contributor.authorBoon, Ai-Ching
dc.contributor.authorClark, Paul J
dc.contributor.authorPowell, Lawrie W
dc.contributor.authorWagner, Karl-Heinz
dc.contributor.authorHeadrick, John P
dc.date.accessioned2019-07-04T12:39:57Z
dc.date.available2019-07-04T12:39:57Z
dc.date.issued2018
dc.identifier.issn0363-6135
dc.identifier.doi10.1152/ajpheart.00417.2017
dc.identifier.urihttp://hdl.handle.net/10072/382138
dc.description.abstractBilirubin, a potentially toxic catabolite of heme and indicator of hepatobiliary insufficiency, exhibits potent cardiac and vascular protective properties. Individuals with Gilbert’s syndrome (GS) may experience hyperbilirubinemia in response to stressors including reduced hepatic bilirubin excretion/increased red blood cell breakdown, with individuals usually informed by their clinician that their condition is of little consequence. However, GS appears to protect from all-cause mortality, with progressively elevated total bilirubin associated with protection from ischemic heart and chronic obstructive pulmonary diseases. Bilirubin may protect against these diseases and associated mortality by reducing circulating cholesterol, oxidative lipid/protein modifications, and blood pressure. In addition, bilirubin inhibits platelet activation and protects the heart from ischemia-reperfusion injury. These effects attenuate multiple stages of the atherosclerotic process in addition to protecting the heart during resultant ischemic stress, likely underpinning the profound reduction in cardiovascular mortality in hyperbilirubinemic GS. This review outlines our current knowledge of and uses for bilirubin in clinical medicine and summarizes recent progress in revealing the physiological importance of this poorly understood molecule. We believe that this review will be of significant interest to clinicians, medical researchers, and individuals who have GS.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.publisher.placeUnited States
dc.relation.ispartofpagefromH429
dc.relation.ispartofpagetoH447
dc.relation.ispartofissue3
dc.relation.ispartofjournalAmerican Journal of Physiology - Heart and Circulatory Physiology
dc.relation.ispartofvolume315
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchMedical physiology not elsewhere classified
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3208
dc.subject.fieldofresearchcode320899
dc.subject.fieldofresearchcode3201
dc.titleBilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorHeadrick, John P.
gro.griffith.authorDu Toit, Eugene
gro.griffith.authorBulmer, Andrew C.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record