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dc.contributor.authorMosaiab, Tamim
dc.contributor.authorBoiteux, Sandra
dc.contributor.authorZulfiker, Abu Hasanat Md
dc.contributor.authorWei, Ming Q
dc.contributor.authorKiefel, Milton J
dc.contributor.authorHouston, Todd A
dc.date.accessioned2019-05-29T13:14:10Z
dc.date.available2019-05-29T13:14:10Z
dc.date.issued2018
dc.identifier.issn1439-4227
dc.identifier.doi10.1002/cbic.201800150
dc.identifier.urihttp://hdl.handle.net/10072/382145
dc.description.abstractGlycolipids from Mycobacterium tuberculosis have a profound impact on the innate immune response of the host. Macrophage‐inducible C‐type lectin (Mincle) is a pattern‐recognition receptor that has been shown to bind trehalose dimycolate (TDM) from the mycobacterium and instigate intracellular signalling in the immune cell. There are structural similarities between the structures of TDM and phosphatidyl inositol mannoside (PIM). We thus hypothesized that these latter structures might also modulate an immune response in a similar manner. To test this, we synthesized a series of new mannose derivatives modified with fatty esters at the 6‐position and assessed the release of inflammatory cytokines in human U937 macrophages under the induction of lipopolysaccharides (LPS) after glycolipid treatment. The results showed that the amount of two major cytokines—tumour necrosis factor (TNF)‐α and interleukin (IL)‐6—released from LPS‐stimulated U937 cells decreased significantly when compared to a control upon treatment with the prepared glycolipids, thus indicating a reduction in cytokine production by the macrophages.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeGermany
dc.relation.ispartofpagefrom1476
dc.relation.ispartofpageto1481
dc.relation.ispartofissue4
dc.relation.ispartofjournalChemBioChem
dc.relation.ispartofvolume19
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310199
dc.subject.keywordsInflammation
dc.subject.keywordsLectins
dc.subject.keywordsMacrophages
dc.subject.keywordsMincle
dc.subject.keywordsMannose
dc.titleA Simple Glycolipid Mimic of the Phosphatidylinositol Mannoside Core from Mycobacterium tuberculosis Inhibits Macrophage Cytokine Production
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyAn Unassigned Group, An Unassigned Department
gro.hasfulltextNo Full Text
gro.griffith.authorKiefel, Milton
gro.griffith.authorHouston, Todd A.
gro.griffith.authorWei, Ming Q.


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