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dc.contributor.authorWright, AA
dc.contributor.authorTodorovic, M
dc.contributor.authorTello-Velasquez, J
dc.contributor.authorRayfield, AJ
dc.contributor.authorSt John, JA
dc.contributor.authorEkberg, JA
dc.date.accessioned2019-07-04T12:39:58Z
dc.date.available2019-07-04T12:39:58Z
dc.date.issued2018
dc.identifier.issn0963-6897
dc.identifier.doi10.1177/0963689718759472
dc.identifier.urihttp://hdl.handle.net/10072/382146
dc.description.abstractAutologous olfactory ensheathing cell (OEC) transplantation is a promising therapy for spinal cord injury; however, the efficacy varies between trials in both animals and humans. The main reason for this variability is that the purity and phenotype of the transplanted cells differs between studies. OECs are susceptible to modulation with neurotrophic factors, and thus, neurotrophins can be used to manipulate the transplanted cells into an optimal, consistent phenotype. OEC transplantation can be divided into 3 phases: (1) cell preparation, (2) cell administration, and (3) continuous support to the transplanted cells in situ. The ideal behaviour of OECs differs between these 3 phases; in the cell preparation phase, rapid cell expansion is desirable to decrease the time between damage and transplantation. In the cell administration phase, OEC survival and integration at the injury site, in particular migration into the glial scar, are the most critical factors, along with OEC-mediated phagocytosis of cellular debris. Finally, continuous support needs to be provided to the transplantation site to promote survival of both transplanted cells and endogenous cells within injury site and to promote long-term integration of the transplanted cells and angiogenesis. In this review, we define the 3 phases of OEC transplantation into the injured spinal cord and the optimal cell behaviors required for each phase. Optimising functional outcomes of OEC transplantation can be achieved by modulation of cell behaviours with neurotrophins. We identify the key growth factors that exhibit the strongest potential for optimizing the OEC phenotype required for each phase.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCognizant Communication Corp.
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom867
dc.relation.ispartofpageto878
dc.relation.ispartofissue6
dc.relation.ispartofjournalCell Transplantation
dc.relation.ispartofvolume27
dc.subject.fieldofresearchBiological Sciences not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchTechnology
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode069999
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode10
dc.subject.fieldofresearchcode11
dc.titleEnhancing the Therapeutic Potential of Olfactory Ensheathing Cells in Spinal Cord Repair Using Neurotrophins
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.rights.copyright© 2018 Cognizant Communication Corporation. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorTodorovic, Michael
gro.griffith.authorSt John, James A.
gro.griffith.authorEkberg, Jenny A.
gro.griffith.authorTello Velasquez, Johana P.
gro.griffith.authorRayfield, Andrew J.
gro.griffith.authorWright, Alison A.


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